Adenosine: A Key Link between Metabolism and Brain Activity Book PDF. Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.
Adenosine: A Key Link between Metabolism and Brain Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. Adenosine: A Key Link between Metabolism and Brain Activity also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Table of Contents
Adenosine: A Key Link between Metabolism and Brain Activity Table of Contents
Part I Introduction
Adenosine and Metabolism—A Brief Historical Note
Part II Molecular Biology, Pharmacology, and Cell Biology of Adenosine
Adenosine Metabolism, Adenosine Kinase, and Evolution
Adenosine and Energy Metabolism—Relationship to Brain Bioenergetics
Adenosine and Autocrine Metabolic Regulation of Neuronal Activity
Physiologic and Metabolic Regulation of Adenosine: Mechanisms
The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books
Downstream Pathways of Adenosine
Astrocytic ATP Release
Role of Striatal A2A Receptor Subpopulations in Neurological Disorders
Part III Adenosine Function and Dysfunction in Brain Health and Disease
Sleep and Adenosine: Human Studies
Adenosine and Other Purinergic Products in Circadian Timing
Adenosine in the Immune System
The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation
Adenosine and Stroke
The Many Roles of Adenosine in Traumatic Brain Injury
Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury
Adenosine and Pain
Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson’s Disease
Adenosine Receptors and Alzheimer’s Disease
Adenosine Receptors in Huntington’s Disease
Adenosine and Multiple Sclerosis
Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis
The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation
Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities
Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes
Part IV Adenosine-Based Therapies
Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation
Ketogenic Diet and Epilepsy: The Role of Adenosine
Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery
Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy
