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Clinical Medicine of the Dog and Cat 4th Edition

Clinical Medicine of the Dog and Cat 4th Edition

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By Michael Schaer, Frederic Gaschen and Stuart Walton

Clinical Medicine of the Dog and Cat 4th Edition remains the most extensively illustrated and practical small animal veterinary textbook on the market.

It continues and expands on the revolutionary problem-based approach of the previous three editions, with more than 1,100 clinical color photographs, diagrams, and tables. The book is divided into five color-coded sections—General Approach, Diagnostic Techniques, Disease of Specific Organ Systems, Multisystemic Disorders, and Elements of Therapy.

The practical information is presented with text, tables, and algorithms, while each chapter is arranged to provide the definition of each disorder, its clinical features, the differential diagnoses, the diagnostic methodology, and the treatment and prognosis. The formatting has been improved to make this textbook easy to read and comprehend. The busy veterinarian or student is thus provided with a readily available resource of important clinical information in a clear, brief manner.

Written by board-certified experts, the topics are carefully selected to make this a valuable resource for veterinary students as well as for general practitioners and small animal interns.

Features

  • Case studies are integrated within the relevant chapters for ease of reference
  • The first section on common medical problems now includes abdominal distension, peripheral edema, proteinuria, regurgitation, and seizures
  • Chapters on thoracic and abdominal radiographs are now included in a unique new section on Diagnostic Techniques, encouraging an integrated learning approach
  • The third section contains detailed medical information covering most organ systems, with several chapters completely rewritten and others comprehensively updated to include additional text and images
  • Additional endoscopic, radiographic, CT, and MRI images are included alongside clinical photographs; very few veterinary textbooks have such a rich emphasis on photographs
  • Each section has a limited number of recommended updated references.

Table of Contents

Table of Contents:

SECTION I: GENERAL APPROACH.

  1. Client Communication and Medical History.

2. Common Clinical Problems.

2.1 Abdominal distension.

2.2 Cough

2.3 Diarrhea.

2.4 Dyspnea.

2.5 Dysuria.

2.6 Epistaxis.

2.7 Fever of Unknown Origin.

2.8 Icterus.

2.9 Pallor.

2.10 Peripheral edema.

2.11 Pigmenturia.

2.12 Polydipsia/Polyuria.

2.13 Proteinuria.

2.14 Regurgitation.

2.15 Seizures.

2.16 Syncope, Episodic Weakness, Collapse.

2.17 Vomiting.

SECTION II: DIAGNOSTIC TECHNIQUES

3. Approach to Thoracic Radiographs

4. Approach to Abdominal Radiographs.

SECTION III: DISEASES OF SPECIFIC ORGAN SYSTEMS

5. Diseases of the Oral Cavity and Teeth

6. Respiratory Disorders – upper and lower

7. Diseases of the Pleural Space

8. Cardiovascular Disorders

9. Digestive Diseases

10. Hepatobiliary Disease

11. Pancreatic Disorders

12. Endocrine Diseases

13. Uro-nephrology

14. Disorders of the Nervous System and Muscle

15. Musculoskeletal Disorders and Injuries

16. Hematologic Disorders

17. Disorders of Hemostasis

18. Dermatologic Disorders

19. Ocular manifestations of systemic diseases.

SECTION IV: Multisystemic Disorders

20. Clinical Toxicology

21. Infectious Diseases

21.1. Dogs

21.2 Cats

22. Immunologic Disorders

SECTION V: Elements of Therapy

23. Fluid Therapy

24. Pain Management

25. Nutrition of the Critically Ill Dog and Cat

26. Management of the Obese Dog and Cat

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The Body of Domestic Animals Structure and Function

Select The Body of Domestic Animals Structure and Function The Body of Domestic Animals Structure and Function

The Body Of Domestic Animals Structure And Function Pdf Download

By John Ikonomopoulos

Achilles’ Heel in Your Dog? Yoda’s Neck in a Giraffe? Discover the Foundations of Animal Life!

Why is tendonitis linked to a Greek hero? How does Star Wars illustrate animal anatomy? And what causes medieval panic over a tiny parasite? Dive into the building blocks of animal life with Part 1 of this engaging popular science series.

Features:

  • Skeletal & Muscular Systems: Uncover the story behind Achilles and tendonitis. Understand why horses might refuse a jump, the critical importance of neck flexibility (think Yoda!), and how structure dictates movement.
  • Nervous System & Sensory Organs: Learn the devastating impact of a dislocated disk and journey back in time to understand the panic caused by the “fearful thread” parasite. Explore how animals perceive their world.
  • Cardiovascular System: Why might pregnant cows faint? Follow veterinarian Dr. Hippocrates as he recounts the real-world experience of diagnosing heartworm disease for the first time.
  • Your Guide Through Science & Story: Led by veterinarian and professor Dr. Hippocrates, this book connects anatomy and physiology to history, mythology, etymology (the origin of scientific terms!), and compelling real-life veterinary cases.
  • Perfect for: Anyone seeking a foundational understanding of how animal bodies are built and controlled. Ideal for animal lovers, aspiring vets, science buffs, and curious minds who enjoy learning through fascinating connections.
Table of Contents

Table of Contents:

1. General Anatomy and Terminology
2. The Locomotor Apparatus
3. Osteology
4. Arthrology
5. Myology
6. The Nervous System
7. The Sense Organs
8. The Integumentary System
9. The Circulatory System
10. The Lymphatic System
11. The Respiratory System
12. The Digestive System
13. The Urinary System
14. The Reproductive System
15. Endocrine Glands
16. The Common Integument and Skin Appendages
17. The Head and Its Organs
18. The Neck, Thorax, and Abdomen
19. The Pelvis and Perineum
20. The Forelimb
21. The Hindlimb
22. Topographical Anatomy
23. Clinical and Functional Anatomy Applications

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Wildlife Crime: From Theory to Practice

Wildlife Crime: From Theory to Practice

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By William D. Moreto

Wildlife Crime: From Theory to Practice examine topical issues from extinction to trafficking in order to understand the ecological, economic, political, and social costs and consequences of these crimes. Drawing from diverse theoretical perspectives, empirical and methodological developments, and on-the-ground experiences of practitioners, this comprehensive volume looks at how conservationists and law enforcement grapple with and combat environmental crimes and the profitable market for illegal trade.

Chapters cover criminological perspectives on species poaching, unregulated fishing, the trading of ivory and rhino horns, the adoption of conservation technologies, and ranger workplaces and conditions. The book includes firsthand experiences and research from China, Indonesia, Kenya, Madagascar, Morocco, Peru, Russia, South Africa, Tanzania, and the United States. The result is a significant book about the causes of and response to wildlife crime.

Contributors include: Johan Bergenas, Avi Brisman, Craig Forsyth, Meredith Gore, Georg Jaster, Alex Killion, Kasey Kinnard, Antony C. Leberatto, Barney Long, Nerea Marteache, Gohar Petrossian, Jonah Ratsimbazafy, Gary Roloff, Viviane Seyranian, Louise Shelley, Rohit Singh, Nicole Sintov, Nigel South, Milind Tambe, Daan van Uhm, Greg Warchol, Rodger Watson, Rob White, Madelon Willemsen, and the editor.

Table of Contents

Table of Contents:

  1. Introduction to Wildlife Crime

  2. Defining Wildlife Crime

  3. Theoretical Perspectives on Wildlife Crime

  4. Wildlife Crime and Criminology

  5. Wildlife Law and Policy

  6. Enforcement of Wildlife Law

  7. Forensic Science in Wildlife Crime Investigations

  8. Community Engagement and Education

  9. Case Studies in Wildlife Crime

  10. Technology and Wildlife Crime Prevention

  11. International Cooperation and Agreements

  12. Challenges in Combating Wildlife Crime

  13. Future Directions in Wildlife Crime Research

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Saving Animals: Multispecies Ecologies of Rescue and Care

Saving Animals: Multispecies Ecologies of Rescue and Care

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By Elan Abrell

Saving Animals: Multispecies Ecologies of Rescue and Care. In the past three decades, animal rights advocates have established everything from elephant sanctuaries in Africa to shelters that rehabilitate animals used in medical testing, to homes for farmed animals, abandoned pets, and entertainment animals that have outlived their “usefulness.” Saving Animals is the first major ethnography to focus on the ethical issues animating the establishment of such places, where animals who have been mistreated or destined for slaughter are allowed to live out their lives simply being animals.

Based on fieldwork at animal rescue facilities across the United States, Elan Abrell asks what “saving,” “caring for,” and “sanctuary” actually mean. He considers sanctuaries as laboratories where caregivers conceive and implement new models of caring for and relating to animals. He explores the ethical decision making around sanctuary efforts to unmake property-based human–animal relations by creating spaces in which humans interact with animals as autonomous subjects. Saving Animals illustrates how caregivers and animals respond by cocreating new human–animal ecologies adapted to the material and social conditions of the Anthropocene.

Bridging anthropology with animal studies and political philosophy, Saving Animals asks us to imagine less harmful modes of existence in a troubled world where both animals and humans seek sanctuary.

Table of Contents

Table of Contents:

Introduction

1. Coming to Sanctuary

2. Care and Rescue

3. Creating and Operating Sanctuaries

4. Animal DeathConclusion: Why Do Sanctuaries Matter?

Acknowledgments

Notes

Bibliography

Index

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Phylogenetics of Bees

Phylogenetics of Bees

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By Rustem Abuzarovich Ilyasov, Hyung Wook Kwon

Phylogenetics of Bees Book. Bees are flying insects of the order Hymenoptera closely related to wasps and ants. The ancestors of bees are assumed to be predatory wasps, which switched to pollen consumption. Further, bees co-evolved with flowering plants and divided into several species according to climatic conditions. Widely known bees are western bees Apis mellifera, and eastern bees Apis cerana. This book sheds light on features of evolution, phylogenesis, speciation, adaptation to environment, and taxonomy of bees. It will be of particular relevance to evolutionists, geneticists, taxonomists, ecologists, population geneticist, and breeders.

Table of Contents

Table of Contents:

The origin and evolution of the colony in Apidae

  1. Phylogenies of Asian honey bees
  2. The origin of the European bees and their intraspecific biodiversity
  3. The classic taxonomy of Asian and European honey bees
  4. Genetic diversity of honey bee Apis mellifera in Siberia
  5. Current drivers of taxonomic biodiversity loss in Asian and European bees
  6. The loss of taxonomic biodiversity of honey bees Apis mellifera and main breeds in Russia
  7. Breeding better and healthy honey bees is the only way to save a native biodiversity

Honey bees in Latin America

8. The history of honey bees in North America

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Microbiology: A Laboratory Manual, 12th Edition

Microbiology: A Laboratory Manual, 12th Edition

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By James Cappuccino , Chad Welsh

Microbiology: A Laboratory Manual 12th Edition gives students the flexibility to take only what they need to class and add their own notes—all at an affordable price.

For courses in Microbiology Lab and Nursing and Allied Health Microbiology Lab.

Foundations in microbiology lab work with a clinical and critical-thinking emphasis

Microbiology: A Laboratory Manual, 12th Edition provides students with a solid underpinning of microbiology laboratory work while putting increased focus on clinical applications and critical-thinking skills, as required by today’s instructors. The text is clear, comprehensive, and versatile, easily adapted to virtually any microbiology lab course and easily paired with any undergraduate microbiology text.

The 12th Edition has been extensively updated to enhance the student experience and meet instructor requirements in a shifting learning environment. Updates and additions include clinical case studies, equipment and material checklists, new experiments, governing body guidelines, and more.

Table of Contents

Table of Contents:

Part 1   Basic Laboratory Techniques for Isolation, Cultivation, and Cultural

Experiment 1: Effectiveness of Hand Washing

Experiment 2: Culture Transfer Techniques

Experiment 3:  Techniques for Isolation of Pure Cultures

Experiment 4: Cultural Characteristics of Microorganisms

Part 2   Microscopy 

Experiment 5: Microscopic Examination of Stained Cell Preparations

Experiment 6:Microscopic Examination of Living Microorganisms Using a Hanging-Drop Preparation or a Wet Mount

Part 3   Bacterial Staining 

Experiment 7: Preparation of Bacterial Smears

Experiment 8: Simple Staining

Experiment 9: Negative Staining

Experiment 10:Gram Stain

Experiment 11: Acid-Fast Stain

Experiment 12: Differential Staining for Visualization of Bacterial Cell Structures

Part 4   Cultivation of Microorganisms: Nutritional and Physical Requirements, and Enumeration of Microbial Populations 

Experiment 13:Nutritional Requirements: Media for the Routine Cultivation of Bacteria

Experiment 14: Use of Differential, Selective, and Enriched Media

Experiment 15: Physical Factors: Temperature

Experiment 16: Physical Factors: pH of the Extracellular Environment

Experiment 17: Physical Factors: Atmospheric Oxygen Requirements

Experiment 18: Techniques for the Cultivation of Anaerobic Microorganisms

Experiment 19: Serial Dilution–Agar Plate Procedure to Quantitate Viable Cells

Experiment 20: The Bacterial Growth Curve

Part 5   Biochemical Activities of Microorganisms 

Experiment 21: Extracellular Enzymatic Activities of Microorganisms

Experiment 22: Carbohydrate Fermentation

Experiment 23: Triple Sugar–Iron Agar Test

Experiment 24: IMViC Test

Experiment 25: Hydrogen Sulfide Test

Experiment 26: Urease Test

Experiment 27: Litmus–Milk Reactions

Experiment 28: Nitrate Reduction Test

Experiment 29: Catalase Test

Experiment 30: Oxidase Test

Experiment 31: Utilization of Amino Acids

Experiment 32: Genus Identification of Unknown Bacterial Cultures

Part 6   The Protozoa 

Experiment 33: Free-Living Protozoa

Experiment 34: Parasitic Protozoa

Part 7   The Fungi 

Experiment 35: Cultivation and Morphology of Molds

Experiment 36: Isolation of a Soil Fungal Species

Experiment 37:Morphology, Cultural Characteristics and Reproduction

Part 8   The Viruses 

Experiment 38: Cultivation and Enumeration of Bacteriophages

Experiment 39: Isolation of Coliphages from Raw Sewage

Experiment 40: Propagation of Isolated Bacteriophage Cultures

Part 9   Physical and Chemical Agents for the Control of Microbial Growth 

Experiment 41: Physical Agents of Control: Moist Heat

Experiment 42: Chemical Agents of Control: Chemotherapeutic Agents

Experiment 43: Determination of Penicillin Activity in the Presence and Absence of Penicillinase

Experiment 44: Chemical Agents of Control: Disinfectants and Antiseptics

Part 10  Microbiology of Food 

Experiment 45: Microbiological Analysis of Food Products: Bacterial Count

Experiment 46: Isolation of Salmonella from Raw Meat

Experiment 47: Microbial Fermentation

PART 11  Microbiology of Water 

Experiment 48: Standard Qualitative Analysis of Water

Experiment 49: Quantitative Analysis of Water: Membrane Filter Method

PART 12   Microbiology of Soil 

Experiment 50: Microbial Populations in Soil: Enumeration

Experiment 51: Isolation of Antibiotic-Producing Microorganisms and Determination of Antimicrobial Spectrum of Isolates

Experiment 52: Isolation of Pseudomonas Species by Means of the Enrichment Culture Technique

PART 13   Bacterial Genetics 

Experiment 53: Enzyme Induction

Experiment 54: Bacterial Conjugation

Experiment 55: Isolation of a Streptomycin-Resistant Mutant

Experiment 56: The Ames Test: A Bacterial Test System for Chemical Carcinogenicity

Experiment 57: Utilization of Bacterial Plasmids

Experiment 58: Restriction Analysis and Electrophoretic Separation of Bacteriophage Lambda DNA

PART 14    Medical Microbiology 

Experiment 59: Microbial Flora of the Mouth: Determination of Susceptibility to Dental Caries

Experiment 60: Normal Microbial Flora of the Throat and Skin

Experiment 61: Identification of Human Staphylococcal Pathogens

Experiment 62: Identification of Human Streptococcal Pathogens

Experiment 63: Identification of Streptococcus pneumoniae

Experiment 64: Identification of Enteric Microorganisms Using Computer-Assisted Multitest Microsystems

Experiment 65: Isolation and Presumptive Identification of Campylobacter

Experiment 66: Microbiological Analysis of Urine Specimens

Experiment 67: Microbiological Analysis of Blood Specimens

Experiment 68: Species Identification of Unknown Bacterial Cultures

PART 15   Immunology

Experiment 69: Precipitin Reaction: The Ring Test

Experiment 70: Agglutination Reaction: The Febrile Antibody Test

Experiment 71: Enzyme-Linked Immunosorbent Assay

Experiment 72: Sexually Transmitted Diseases: Rapid Immunodiagnostic Procedures

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Ecological and Environmental Physiology of Mammals

Ecological and Environmental Physiology of Mammals

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By Philip C. Withers, Christine E. Cooper, Shane K. Maloney, Francisco Bozinovic, Ariovaldo P. Cruz Neto

Ecological and Environmental Physiology of Mammals Mammals are the so-called “pinnacle” group of vertebrates, successfully colonising virtually all terrestrial environments as well as the air (bats) and sea (especially pinnipeds and cetaceans). How mammals function and survive in these diverse environments has long fascinated mammologists, comparative physiologists and ecologists.

Ecological and Environmental Physiology of Mammals explores the physiological mechanisms and evolutionary necessities that have made the spectacular adaptation of mammals possible. It summarises our current knowledge of the complex and sophisticated physiological approaches that mammals have for survival in a wide variety of ecological and environmental contexts: terrestrial, aerial, and aquatic. The authors have a strong comparative and quantitative focus in their broad approach to exploring
mammal ecophysiology. As with other books in the Ecological and Environmental Physiology Series, the emphasis is on the unique physiological characteristics of mammals, their adaptations to extreme environments, and current experimental techniques and future research directions are also considered.

This accessible text is suitable for graduate level students and researchers in the fields of mammalian comparative physiology and physiological ecology, including specialist courses in mammal ecology. It will also be of value and use to the many professional mammologists requiring a concise overview of the topic.

Table of Contents

Table of Contents:

1. Introduction to Mammals

2. General Physiological Principles

3. Physiological Characteristics of Mammals

4. Physiological Adaptations to Extreme Environments

5. Concepts, Approaches, Techniques, and Applications

6. Conclusions and Future Directions

Appendix

References

Index

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Climate, Ticks and Disease

Climate, Ticks and Disease

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By Pat Nuttall

Climate, Ticks and Disease book brings together expert opinions from scientists to consider the evidence for climate change and its impacts on ticks and tick-borne infections, and provide predictions for the future. It considers what is meant by “climate change,” how relevant climate models are to ecosystems, and predictions for changes in climate at global, regional, and local scales relevant for ticks and tick-borne infections. It examines changes to tick distribution and the evidence that climate change is responsible. The effect of climate on the physiology and metabolism of ticks, including potentially critical impacts on the tick microbiome is stressed. Given that the notoriety of ticks derives from pathogens they transmit, do changes in climate affect vector capacity? Ticks transmit a remarkable range of micro- and macro-parasites many of which are pathogens of humans and domesticated animals. The intimacy between tick-borne agent and tick vector means that any impacts of climate on a tick vector will impact tick-borne pathogens. Most obviously, such impacts will be apparent as changes in disease incidence and prevalence. The evidence that climate change is affecting diseases caused by tick-borne pathogens is considered, along with the potential to make robust predictions of future events.

Table of Contents

Table of Contents:

Section 1: Climate
Section 1.1: Climate and the tick ecosystem
eo1: Future climate of Africa
eo2: Vegetation-climate interactions: into the tick zone
Section 1.2: Modelling climate change impacts
eo3: Climate change and Lyme disease
eo4: How to Model the Impact of Climate Change on Vector-Borne Diseases?
eo5: Challenges of Modelling and Projecting Tick Distributions
eo6: Considerations for predicting climate change implications on future spatial distribution ranges of ticks
Section 1.3 Synopsis: Climate
Section 2: Ticks
Section 2.1: Climate impacts on tick physiology
eo7: Can the impact of climate change on the tick microbiome bring a new epidemiological landscape to tick-borne diseases?
eo8: Climate influence on tick neurobiology
eo9: The impact of climate change on tick host-seeking behaviour
eo10: Expected transitions in ticks and their heritable endosymbionts under environmental changes
eo11: Drought and tick dynamics during climate change
eo12: Climate influences on reproduction and immunity in the soft tick, Ornithodoros moubata
eo13: Climate change and ticks: measuring impacts
Section 2.2: Climate impacts on tick populations
eo14: Scandinavia and ticks in a changing climate
eo15: Birds, ticks and climate change
eo16: How tick vectors are coping with global warming
eo17: Possible direct and human-mediated impact of climate change on tick populations in Turkey
eo18: Climate change alone cannot explain altered tick distribution across Europe: a spotlight on endemic and invasive tick species
eo19: Climate and management effects on tick–game animal dynamics
eo20: Climate-driven livestock management shifts and tick populations
eo21: Potential impacts of climate change on medically important tick species in North America
Section 2.3: Climate impacts on tick species
eo22: Climate change and tick evolution: lessons from the past
Chapter 23: Amblyomma ticks and future climates
Chapter 24: Climate impacts on Dermacentor reticulatus tick population dynamics and range
Chapter 25: Changes expected in Ixodes ricinus temporal and spatial distribution in Europe
Chapter 26: Range expansion of Ixodes scapularis in the USA
Chapter 27: Distribution, seasonal occurrence, and biological characteristics of Haemaphysalis longicornis, a vector of bovine piroplasmosis in Japan
Chapter 28: Climate and vector potential of medically important North American ticks
Chapter 29: The impact of climate change on the biology of the cattle tick, Rhipicephalus microplus: current knowledge and gaps to be filled
Section 2.4: Climate impacts on vector capacity
Chapter 30: Climate impacts on the vector capacity of tropical and temperate populations of the brown dog tick, Rhipicephalus sanguineus sensu lato
Chapter 31: Argasidae: distribution and vectorial capacity in a changing global environment
Chapter 32: Effects of climate change on babesiosis vectors
Section 2.5: Synopsis: Ticks
Section 3: Disease
Section 3.1: Vector–host–pathogen triangle
Chapter 33: Conflict and cooperation in tick–host–pathogen interactions contribute to increased tick fitness and survival
Chapter 34: Climate, ticks, and pathogens: gaps and caveats
Chapter 35: Climate and prediction of tick-borne diseases facing the complexity of the pathogen–tick–host triad at northern latitudes
Chapter 36: Is the clock ‘ticking’ for climate change?
Chapter 37: Climate instability and emerging tick-borne disease
Chapter 38: Co-infections of ticks
Chapter 39: Impact of climate change on co-feeding transmission
Chapter 40: Human behaviour trumps entomological risk
Chapter 41: It’s all in the timing: effect of tick phenology on pathogen transmission dynamics
Chapter 42: Anaplasma species’ novel tick–host–pathogen relationships and effects of climate change
Chapter 43: Zoonotic potential in the genera Anaplasma and Ehrlichia
Chapter 44: Tick vectors, tick-borne diseases and climate change
Chapter 45: Climate and other global factors at the zoonotic interface in America: influence on diseases caused by tick-borne pathogens
Chapter 46: Microclimatic conditions and RNA viruses in ticks
Section 3.2: Vector-borne infections of humans
Chapter 47: Climate, ticks and tick-borne encephalitis in Central Europe
Chapter 48: Tick-borne viral haemorrhagic fever infections
Chapter 49: Climate impact on Lyme borreliosis and its causative agents
Chapter 50: Climate change and tick-borne encephalitis in the Greater Alpine Region
Chapter 51: The expansion of Japanese spotted fever and the complex group of spotted fever group rickettsia in Japan
Chapter 52: Spatiotemporal and demographic patterns of transmission of Kyasanur Forest Disease virus in India
Chapter 53: Argasid ticks, relapsing fever and a changing climate
Chapter 54: The potential effects of climate change on Lyme borreliosis in East-Central Europe
Chapter 55: Epidemiology of severe fever with thrombocytopenia syndrome in China
Chapter 56: Climate change and debilitating symptom complexes attributed to ticks in Australia
Chapter 57: Effect of climate change on mosquito-borne pathogens
Section 3.3: Vector-borne infections of domesticated animals
Chapter 58: Ornithodoros tick vectors and African swine fever virus
Chapter 59: Tick-borne diseases of livestock in the UK
Chapter 60: Impact of climate change on tick-borne diseases of livestock in Pakistan – looking ahead
Chapter 61: The emergence of tick-borne diseases in domestic animals in Australia
Section 3.4: Vector-borne infections in different regions
Chapter 62: Tick-borne infections in Central Europe
Chapter 63: Impact of climate change on ticks and tick-borne infections in Russia
Chapter 64: Is climate change affecting ticks and tick-borne diseases in Taiwan?
Chapter 65: Ticks and tick-borne pathogens in the Caribbean region in the context of climate change
Chapter 66: The strange case of tick-borne viruses in Turkey
Chapter 67: Melting, melting pot – climate change and its impact on ticks and tick-borne pathogens in the Arctic
Chapter 68: Ticks and tick-borne diseases in the Middle East
Chapter 69: The emergence of ticks and tick-borne diseases in the United States
Chapter 70: Role of climate and other factors in determining the dynamics of tick and tick-transmitted pathogen populations and distribution in western, central, and eastern Africa
Chapter 71: Tick-borne pathogens in China
Chapter 72: Tick-borne rickettsioses in Africa
Chapter 73: Climate and the emergence of tick-borne disease in Canada
Chapter 74: Climate change impacts on Ixodes ricinus in Scotland and implications for Lyme disease risk
Chapter 75: Possible impact of climate and environmental change on ticks and tick-borne disease in England
Chapter 76: Climate change, ticks and tick-borne pathogens in northern Europe
Chapter 77: Tick and tick-borne disease circulation in a changing marine ecosystem
Section 3.5: Synopsis: Disease
Section 4: Final synopsis and future predictions

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Basic Principles of Drug Discovery and Development 2nd Edition

Basic Principles of Drug Discovery and Development 2nd Edition

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By Benjamin E. Blass

Basic Principles of Drug Discovery and Development 2nd Edition presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics.

Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.

Features

Features:

  • Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property
  • Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape
  • Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery
  • Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry

Table of Contents

Table of Contents:

1. Drug Discovery and Development: An Overview of Modern Methods and Principles
2. The Drug Discovery Process: From Ancient Times to the Present Day
3. Classical Targets in Drug Discovery
4. In Vitro Screening Systems
5. Medicinal Chemistry
6. In vitro ADME and In vivo Pharmacokinetics
7. Animal Models of Disease States
8. Safety and Toxicology
9. Antibody Drug Discovery
10. Basics of Clinical Trials
11. Translational Medicine and Biomarkers
12. Organizational Considerations and Trends in the Pharmaceutical Industry
13. Intellectual Property and Patents in Drug Discovery
14. Case Studies in Drug Discovery

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Animal Coronaviruses, 2nd Edition

Animal Coronaviruses, 2nd Edition

Animal Coronaviruses, 2Nd Edition Pdf Download

By Leyi Wang

Animal Coronaviruses, 2nd Edition provides diagnosticians and researchers with practical methodologies and approaches to tackle animal coronaviruses. It explores conventional immunohistochemistry, virus neutralization, enzyme-linked immunosorbent assays, expression and purification of recombinant viral proteins, and various molecular assays, including conventional and real-time reverse transcription-PCR, reverse genetics methodology, and next generation sequencing and sequence analyses. As part of the Springer Protocols Handbooks series, chapters contain readily reproducible laboratory protocols as well as expert tips on troubleshooting and avoiding known pitfalls.

Practical and authoritative, Animal Coronaviruses serves as an ideal reference for researchers examining a wide variety of coronavirus species in the Coronaviridae.

Table of Contents

Table of Contents:

1. Animal Coronaviruses

2. Feline Coronavirus: Insights into the Pathogenesis and Diagnosis and Chengming Wang

3. Animal Models for Studying COVID-19 Pathology and Infection

4. Isolation of Porcine Epidemic Diarrhea Virus from Clinical Samples

5. Isolation and Characterization of Porcine Epidemic Diarrhea Virus Using Suspension Vero Cells

6. Isolation and Propagation of Porcine Deltacoronavirus in Cell Culture and Embryonated Chicken Eggs

7. Isolation and Propagation of Infectious Bronchitis Virus (Avian Coronavirus) in Chicken Embryonated Eggs

8. Real-Time Reverse Transcription-Polymerase Chain Reaction for Simultaneous Detection of Bovine Coronavirus and Other Pathogens

9. TaqMan Real-Time RT-PCR Detection of Porcine Epidemic Diarrhea Virus

10. Real-Time RT-PCR for Detection of Feline Coronavirus

11. SARS-CoV-2 Real-Time RT-PCR Assay in Animals.

12. Real-Time PCR and Antigen-Capture ELISA for the Diagnosis

PART IV SEROLOGY
13. Identification of a Neutralizing Epitope-Containing Segment in Turkey Coronavirus Spike Protein for Diagnostic Serology

14. Antibody-Capture Enzyme-Linked Immunosorbent Assay for Detecting Protective Antibodies to Turkey Coronavirus Based on Recombinant Spike Protein Segment with Neutralizing Epitope
15. ELISA, Virus Neutralization, and Immunofluorescence Assays for
Detection of Antibodies Against Porcine Deltacoronavirus.

16. Luminescent Immunoprecipitation System (LIPS) Development for the bSpecific Detection of PDCoV and SARS-CoV-2 Antibodies

17. Construction of a Mouse-Feline Chimeric Neutralizing Antibode Against SARS-CoV-2

18. Microneutralization Test of Avian Infectious Bronchitis Virus Using Vero Cells

PARTV DISEASE-TARGETED ANIMAL SPECIES AS ANIMAL MODELS

19. Pig Bioassay to Assess Infectivity of Porcine Epidemic Diarrhea Virus Detected in Various Sample Matrices

20. Diagnostic Investigation and Confirmation of Emerging Turkey
Coronaviral Enteritis

PART VI NEXT-GENERATION SEQUENCING AND BIOINFORMATICS

21. Whole Genome Sequencing of Porcine Epidemic Diarrhea Virus
and Porcine Deltacoronavirus

22. Whole Genome Sequencing of Avian Infectious Bronchitis Virus
by iSeq100 Platform and MinION

23. Phylogenetic and Recombination Analysis of Animal Coronaviruses

Index

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