Hepatobiliary and Pancreatic Carcinogenesis in the Hamster

By Yoshitsugu Tajima, Tamotsu Kuroki and Takashi Kanematsu

Hepatobiliary and Pancreatic Carcinogenesis in the Hamster PDF. Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Table of Contents

General Information

The Syrian Hamster as an Experimental Animal

Surgical Instruments

Anesthesia of the Laboratory Hamster

Fundamental Surgical Techniques

Experimental Carcinogenesis in the Hamster

Hamster Models of Biliary Carcinoma

Biliary Carcinomas Induced in the Hamster

Biliary Inflammation and Biliary Carcinogenesis

Spontaneous Biliary Carcinogenesis

Modification of Biliary Carcinogenesis

Chemoprevention of Biliary Carcinogenesis

Hamster Model of an Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas

Chemoprevention of Pancreatic Carcinogenesis

Cancer Lines and Biliary Epithelial Cell Lines

Establishment of Transplantable Biliary Cancer Lines

Establishment of Biliary Epithelial Cell Lines from the Hamster

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