Contents
Contributors viii
Preface xiii
Acknowledgement xv
PART I: HISTORY AND EPIDEMIOLOGY
1 Dengue Viruses: Their Evolution, History and Emergence as
a Global Public Health Problem 1
Duane J. Gubler
2 Mapping the Epidemiology of Dengue 30
Oliver J. Brady, Jane P. Messina, Thomas W. Scott and Simon I. Hay
3 Economic and Disease Burden of Dengue 50
Donald S. Shepard, Yara A. Halasa and Eduardo A. Undurraga
4 Surveillance for Dengue 78
Eng Eong Ooi
5 Dengue Infections in Travelers 90
Annelies Wilder-Smith
6 A Review of Transmission Models of Dengue: A Quantitative
and Qualitative Analysis of Model Features 99
T. Alex Perkins, Robert C. Reiner Jr., Isabel Rodriguez-Barraquer,
David L. Smith, Thomas W. Scott and Derek A.T. Cummings
PART II: THE DISEASE
7 Clinical Features of Dengue 115
Dinh The Trung and Bridget Wills
8 Neurological Manifestations of Dengue Virus Infection 145
James J. Sejvar
9 The Southeast Asia Regional Office (WHO) Guidelines
for Clinical Management of Dengue Hemorrhagic Fever 168
Siripen Kalayanarooj
10 Laboratory Diagnosis of Dengue 184
Maria G. Guzman, Phillipe Buchy, Delia Enria and Susana Vazquez
11 Dengue Pathogenesis: Host Factors 214
Jamie Whitehorn, Sonya Hubbard, Katherine L. Anders,
Nguyen Than Ha Quyen and Cameron Simmons
12 Dengue Pathogenesis: Viral Factors 229
Molly OhAinle and Eva Harris
13 The Acquired Immune Response in Dengue Virus Infection 249
Gavin Screaton and Juthathip Mongkolsapaya
14 Innate Immune Responses to Dengue Infection 268
Michael S. Diamond, Adolfo Garcia-Sastre and Ana Fernandez-Sesma
15 Pathology of Dengue Virus Infection 284
Atis Muehlenbachs and Sherif R. Zaki
16 Dengue Drug Development 293
Cynthia Sung, G.B. Sunil Kumar and Subhash G. Vasudevan
PART III: THE VIRUS
17 Taxonomy and Evolutionary Relationships of Flaviviruses 322
Shannon N. Bennett
18 Molecular Virology of Dengue Virus 334
Néstor G. Iglesias, Laura A. Byk and Andrea V. Gamarnik
19 The Structural Biology of Dengue Virus 365
Julien Lescar and Shee-Mei Lok
20 The Nonstructural Proteins of Dengue Virus 377
Keith J. Chappell and Paul R. Young
PART IV: VIRUS–HOST INTERACTION
21 The Interface between Dengue Virus and the Human Host 406
Nicholas J. Barrows, Shelton S. Bradrick, Katell Bidet, Azlinda Anwar,
Alex M. Ward, Sharon F. Jamison, Brandt Levitt, Caroline Le Sommer
and Mariano A. Garcia-Blanco
22 Dengue Virus–Mosquito Interactions and Molecular Methods
of Vector Control 425
Shuzhen Sim, Christopher M. Cirimotich, José L. Ramirez,
Jayme A. Souza-Neto and George Dimopoulos
23 Animal Models of Dengue Infection and Disease 442
Michael D. Buck, Huda A. Makhluf and Sujan Shresta
PART V: DENGUE PREVENTION
24 Dengue Vector Bionomics: Why Aedes aegypti is Such a Good Vector 455
Scott A. Ritchie
25 Surveillance and Control of Urban Dengue Vectors 481
Paul Reiter
26 Dengue Vector Control: New Approaches 519
David M. Brown and Anthony A. James
27 Biological Control of Dengue and Wolbachia-based Strategies 537
Francesca D. Frentiu, Thomas Walker and Scott L. O’Neill
28 Dengue Vaccines 548
Scott B. Halstead
29 Dengue Virus Neutralization and Surrogates of Protection 577
Wahala M.P.B. Wahala and Aravinda M. de Silva
Index
