Adenosine: A Key Link between Metabolism and Brain Activity


Adenosine: A Key Link Between Metabolism And Brain Activity

By Susan Masino and Detlev Boison

Adenosine: A Key Link between Metabolism and Brain Activity Book PDF. Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.

Adenosine: A Key Link between Metabolism and Brain Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. Adenosine: A Key Link between Metabolism and Brain Activity also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Table of Contents

Adenosine: A Key Link between Metabolism and Brain Activity Table of Contents

Part I Introduction

  1. Adenosine and Metabolism—A Brief Historical Note

Part II Molecular Biology, Pharmacology, and Cell Biology of Adenosine

  1. Adenosine Metabolism, Adenosine Kinase, and Evolution
  2. Adenosine and Energy Metabolism—Relationship to Brain Bioenergetics
  3. Adenosine and Autocrine Metabolic Regulation of Neuronal Activity
  4. Physiologic and Metabolic Regulation of Adenosine: Mechanisms
  5. The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books
  6. Downstream Pathways of Adenosine
  7. Astrocytic ATP Release
  8. Role of Striatal A2A Receptor Subpopulations in Neurological Disorders

Part III Adenosine Function and Dysfunction in Brain Health and Disease

  1. Sleep and Adenosine: Human Studies
  2. Adenosine and Other Purinergic Products in Circadian Timing
  3. Adenosine in the Immune System
  4. The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation
  5. Adenosine and Stroke
  6. The Many Roles of Adenosine in Traumatic Brain Injury
  7. Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury
  8. Adenosine and Pain
  9. Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson’s Disease
  10. Adenosine Receptors and Alzheimer’s Disease
  11. Adenosine Receptors in Huntington’s Disease
  12. Adenosine and Multiple Sclerosis
  13. Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis
  14. The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation
  15. Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities
  16. Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes

Part IV Adenosine-Based Therapies

  1. Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation
  2. Ketogenic Diet and Epilepsy: The Role of Adenosine
  3. Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery
  4. Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy


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