Dinoprost Tromethamine

Dinoprost Tromethamine: Uses, Dosage and Side Effects

Overview

• Prostaglandin F2 stimulates uterine contraction, causes cervical relaxation

Uses of Dinoprost tromethamine

• Stimulation of uterine contractions in the treatment of open pyometra.

Dose of Dinoprost tromethamine in Dogs and Cats

Dogs:

• Open pyometra: 0.1–0.25 mg/kg s.c. q12h until the uterus is empty; usually 3–5 days of treatment is required.

Cats:

0.1 or 0.25 mg/kg s.c. q12–24h.

Side Effects of Dinoprost tromethamine in Dogs and Cats

• Hypersalivation, panting, tachycardia, vomiting, urination, defecation, transient hyperthermia, locomotor incoordination, and mild CNS signs have been reported.
• Such effects usually diminish within 30 minutes of drug administration.
• There is no adverse effect on future fertility.

Contraindications of Dinoprost tromethamine in Dogs and Cats

• Do not use it for the treatment of closed pyometra as there is a risk of uterine rupture.