Hyoscine Butylbromide

Hyoscine Butylbromide – in Dogs and Cats : Uses, Dosage and Side Effects (Butylscopolamine, N-butylscopolammonium bromide (NBB), Butylscopolamine Bromide)

Overview

• Trade names: Buscopan
• It inhibits M1 muscarinic acetylcholine receptors in the GI and urinary tracts causing smooth muscle relaxation but does not cross the blood-brain barrier.

Uses of Hyoscine Butylbromide

• Control of diarrhea in dogs, particularly when pain or abdominal discomfort is present.
• Control of pain associated with urinary obstruction in dogs.

Dose of Hyoscine Butylbromide – Buscopan in Dogs and Cats

Dogs:

Control of diarrhea and/or abdominal discomfort:

• 0.1 ml/ kg i.v., i.m. q12h (Buscopan Compositum).
• 0.5 mg/kg i.m., p.o. q12h (butylscopolamine only).

Cats:

Do not use.

Side Effects of Hyoscine Butylbromide in Dogs and Cats

• Dry mouth, blurred vision, hesitant micturition, and constipation at doses acting as gut neuromuscular relaxants.
• The i.m. route may cause a local reaction.

Contraindications of Hyoscine Butylbromide in Dogs and Cats

• Intestinal obstruction.

Some Notes:

• Should only be used in combination with investigations into the cause of abdominal pain or definitive relief of urinary obstruction.
• Metamizole should not be given to dogs that have been treated with phenothiazine, as hypothermia may result.
• Effects may be potentiated by concurrent use of other anticholinergic or analgesic drugs.
• Metoclopramide NBB may counteract one another’s actions on GI Motility.