Estriol (Oestriol)

Estriol (Oestriol): Uses, Dosage and Side Effects

Overview

• Synthetic, short-acting oestrogen with a high affinity for oestrogen receptors in the lower urogenital tract.
• It increases muscle tone, improving urodynamic function.

Uses of Estriol (Oestriol)

• Management of urethral sphincter mechanism incompetence (USMI) that develops in spayed bitches.

Dose of Estriol (Oestriol) in Dogs and Cats

Dogs:

USMI in spayed bitches:

• starting dose = 1 mg/dog p.o. q24h.
• If treatment is successful reduce the dose to 0.5 mg/dog p.o. q24h.
• If treatment is unsuccessful increase to 2 mg/dog p.o. q24h.
• Alternate-day dosing can be considered once a response has been seen.
• The minimum effective dose is 0.5 mg/dog p.o. q24–48h.
• The maximum dose is 2 mg/dog p.o. q24h.

Cats:

Do not use.

Side Effects of Estriol (Oestriol) in Dogs and Cats

• Oestrogenic effects are seen in 5–9% of bitches receiving 2 mg q24h.
• Low risk of bone marrow suppression (consider monitoring CBC for long-term use).

Contraindications of Estriol (Oestriol) in Dogs and Cats

• Do not use in intact bitches.
• Do not use if PU/ PD is present.
• The manufacturer states that this drug should not be used in animals <1 year old.

Some Notes:

• Concurrent administration with phenylpropanolamine may potentiate efficacy.