Deslorelin

Deslorelin: Uses, Dosage and Side Effects

Overview

• Superagonist of GnRH.
• Receptors are stimulated for the first two weeks after application, but then die down due to overstimulation, resulting in decreased LH and FSH production.
• As a result, cessation of testosterone and sperm formation

Uses of Deslorelin

Temporary chemical castration.

Dose of Deslorelin in Dogs and Cats

Dogs:

1 implant per male dog repeats after 6 or 12 months (depending on the size of implant).

Cats:

1 implant (4.7 mg) per male cat.

Side Effects of Deslorelin in Dogs and Cats

• Moderate swelling at the implant site.
• A significant decrease in testicle size will be seen during treatment.

Contraindications of Deslorelin in Dogs and Cats

• Use in bitches causes induction of oestrus within a few days, followed by a long anoestrus period

Some Notes:

• Infertility lasts 6–12 months.
• Treated dogs should stay away from bitches in the heat for 6 weeks after initial treatment (separation unnecessary after future implantations if the product is administered every 6 or 12 months).
• Matings during therapy rarely result in pregnancy.
• Dogs under 10 kg may take 18 months to regain testosterone.
• Deslorelin devices chemically castrate tom cats for 2–4 years.
• Pre-implant site disinfection prevents infection.
• Subcutaneously insert the product between the lower neck and lumbar area.
• In low-vascularized areas, the fat injection may impede active substance release.
• If therapy is discontinued, biocompatible implants can be removed under local anesthesia.