Patient Derived Tumor Xenograft Models, Promise, Potential and Practice
By Rajesh Uthamanthil, Peggy Tinkey and Elisa de Stanchina
Patient Derived Tumor Xenograft Models: Promise, Potential and Practice PDF offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains.
In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory.
Offers guidance on data interpretation and regulatory aspects
Provides useful techniques and strategies for working with PDX models
Includes practical tools and potential pitfalls for best practices
Compiles all knowledge of PDX models research in one resource
Presents the results of first ever global survey on standards of PDX development and usage in academia and industry
Table of Contents
Preface
Section I. Mouse Xenograft Models of Cancer
Chapter 1. PDX Models: History and Development
Chapter 2. History of Mouse Cancer Models
Chapter 3. Challenges and Limitations of Mouse Xenograft Models of Cancer
Chapter 4. Tumor Heterogeneity
Chapter 5. Immunodeficient Mice: The Backbone of Patient-Derived Tumor Xenograft Models
Chapter 6. Humanized Mice and PDX Models
Section II. Components of a PDX Program
Chapter 1. Regulations of Patient-Derived Xenografts
Chapter 2. Acquisition and Storage of Clinical Samples to Establish PDX Models
Chapter 3. Methodologies for Developing and Maintaining Patient-Derived Xenograft Mouse Models
Chapter 4. Pathology of Patient-Derived Xenograft Tumors
Chapter 5. Genetic Profiling of Tumors in PDX Models
Chapter 6. Running a PDX Core Laboratory or a PDX Support Program
Chapter 7. Veterinary Care
Chapter 8. Occupational Health and Safety
Section III. PDX Models for Tumors of Various Organ Systems
Chapter 1. Pediatric and Adult Brain Tumor PDX Models
Chapter 2. Patient-Derived Xenograft Models of Prostate Tumors
Chapter 3. Patient-Derived Xenograft Model of Pancreatic Cancer
Chapter 4. Modeling Breast Cancer Heterogeneity With Patient-Derived Xenografts
Chapter 5. Patient-Derived Xenograft Models of Ovarian/Gynecologic Tumors
Chapter 6. Patient-Derived Xenografts From Lung Cancer and Their Potential Applications
Chapter 7. PDX Models of Colorectal Tumors
Chapter 8. Patient-Derived Tumor Xenografts in Hematologic Disorders
Chapter 9. Patient-Derived Xenografting of Human Melanoma
Chapter 10. Advances in Organoid Culturing of Patient-Derived Tumors
Section IV. PDX Models in Cancer Research and Therapy Around the World
Chapter 1. Global Practices in PDX Programs
Chapter 2. Role of Companies and Corporations in the Development and Utilization of PDX Models
Appendix 1. Additional Information on Some Companies Providing and Supporting PDX Model Development
Section V. Challenges & Future of PDX Models
Chapter 1. Patient-Derived Tumor Xenograft: Present and Future Challenges and Applications
Index
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