Atlas of Histology of the Juvenile Rat PDFÂ should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals.
While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day.
Table of Contents
List of Contributors
Abbreviations
Introduction
Goals
Developmental Stages
Materials and Methods
Acknowledgments
References
Chapter 1. Skin and Mammary Gland
Abstract
Introduction
Skin (Histologic Anatomy and Development)
Histologic Anatomy of the Skin
Postnatal Development of the Skin
Mammary Gland
References
Chapter 2. Musculoskeletal System
Abstract
Introduction
Skeletal Muscle
Bone
References
Chapter 3. Nervous System
Abstract
Introduction
Brain
Spinal Cord
Peripheral Nerves
References
Chapter 4. Respiratory System
Abstract
Introduction
Embryologic Development of the Respiratory Tract
Nasal Cavity
Larynx and Trachea
Bronchi, Bronchioles, and Terminal Bronchioles
Lung
References
Chapter 5. Gastrointestinal Tract
Abstract
Introduction
Control of Postnatal Development
Tongue
Esophagus
Stomach
Small Intestine
Large Intestine
References
Chapter 6. Liver, Exocrine Pancreas, and Salivary Glands
