Atlas of Histology of the Juvenile Rat

By George Parker and Catherine Picut

Atlas of Histology of the Juvenile Rat PDF should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals.

While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day.

Table of Contents

List of Contributors

Abbreviations

Introduction

Goals

Developmental Stages

Materials and Methods

Acknowledgments

References

Chapter 1. Skin and Mammary Gland

Abstract

Introduction

Skin (Histologic Anatomy and Development)

Histologic Anatomy of the Skin

Postnatal Development of the Skin

Mammary Gland

References

Chapter 2. Musculoskeletal System

Abstract

Introduction

Skeletal Muscle

Bone

References

Chapter 3. Nervous System

Abstract

Introduction

Brain

Spinal Cord

Peripheral Nerves

References

Chapter 4. Respiratory System

Abstract

Introduction

Embryologic Development of the Respiratory Tract

Nasal Cavity

Larynx and Trachea

Bronchi, Bronchioles, and Terminal Bronchioles

Lung

References

Chapter 5. Gastrointestinal Tract

Abstract

Introduction

Control of Postnatal Development

Tongue

Esophagus

Stomach

Small Intestine

Large Intestine

References

Chapter 6. Liver, Exocrine Pancreas, and Salivary Glands

Abstract

Introduction

Liver

Exocrine Pancreas

Salivary Glands

References

Chapter 7. Female Reproductive System

Abstract

Introduction

Ovary

Oviduct

Uterus

Cervix

Vagina

References

Chapter 8. Male Reproductive System

Abstract

Introduction

Testes

Epididymis

Vas Deferens

Seminal Vesicles

Prostate Gland

References

Chapter 9. The Endocrine System

Abstract

Introduction

Pituitary Gland

Pancreatic Endocrine Tissue

Thyroid Gland

Parathyroid Gland

Adrenal Gland

References

Chapter 10. Immune System

Abstract

Introduction

Bone Marrow

Thymus

Spleen

Lymph Nodes

Mucosa-Associated Lymphoid Tissue (MALT)

Summary

References

Chapter 11. Hematopoietic System

Abstract

Hematopoiesis

References

Chapter 12. The Eye and Harderian Gland

Abstract

Introduction

Embryological Development of the Eye

Postnatal Development of the Eye

References

Chapter 13. Urinary System

Abstract

Introduction

Kidney

Lower Urinary Tract

References

Chapter 14. Cardiovascular System

Abstract

Introduction

Transition From Fetal to Postnatal Circulation

Heart

Great Vessels

References

Index

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