By Ronald Kaminsky, Timothy G. Geary and Paul M. Selzer
Human and Animal Filariases, Landscape, Challenges, and Control. Filariae are a family of parasitic worms which infect animals and humans, causing severe diseases such as elephantiasis (lymphatic filariasis) and river blindness (onchocerciasis) in humans, as well as heartworm disease (dirofilariasis) in dogs and cats. While the human diseases are rarely fatal, the blindness and disfiguration resulting from these infections constitute a severe burden for the affected individuals and to the healthcare systems in many tropical countries. In 2017, the World Health Organization classified several filariases as neglected tropical diseases and announced a new program seeking to eradicate these infections, which has in turn sparked a new push to develop antifilarial drugs.
Considering the current and future import of this topic, Human and Animal Filariases takes a comprehensive look at infections by filarial parasites in humans and in animals. It begins by reviewing the current state of diagnosis and chemotherapy, before addressing the increasing resistance to available antifilarial drugs. This is followed by strategies and approaches for the discovery of novel drugs and finally by looking at alternative and supplementary approaches to combat the parasites, including vector control and vaccination.
Human and Animal Filariases is a unique reference for parasitologists, veterinarians, as well as professionals in the pharmaceutical industry and in public health agencies.
Features
Features:
- A comprehensive approach that integrates current chemotherapy with recent advances in antifilarial drug discovery
- Practical information on assay development, target validation, and required drug product profiles
- Insights from global experts from leading academic institutions as well as from pharma and healthcare companies
Table of Contents
Table of Contents:
Part I: Human and Animal Filariae and Their Diseases
Breaking the Silos – Obstacles and Opportunities for One Health in Filariases
Filariae as Organisms
Human Filarial Infections: Reflections on the Current Understanding of Their Importance, Pathobiology, and Management
Canine Filariasis (Heartworm) – Disease and Current Gaps
Diagnosis and Assessment of Human Filarial Infections: Current Status and Challenges
Veterinary Diagnosis of Filarial Infection
Antifilarial Chemotherapy: Current Options for Humans
Antifilarial Chemotherapy: Current Options in Veterinary Medicine
Heartworm Disease – Intervention and Industry Perspective
Current Antifilarial Drugs – Mechanisms of Action
Drug Resistance in Filariae
Elimination and Eradication of Human Filariases
Part II: Drug Discovery for Novel Antifilarials
Global Economics of Heartworm Disease
Product Profiles for New Drugs Against Human and Animal Filariasis
Discovery and Development of New Antifilarial Drugs (In Vitro Assays)
In Vivo Models for the Discovery of New Antifilarial Drugs
In Vivo Assays – Discovery and Development of New Antifilarial Drugs in Companion Animals
The Antifilarial Drug Pipeline
Part III: New Frontiers for Control of Antifilarial Diseases
The Host–Helminth Interface as a Rich Resource for Novel Drug Targets
Functional Genomics of Filariae
Development of a Vaccine Against Onchocerca volvulus
Vector Control Approaches to Interrupt Transmission of Human Filarial Parasites
Vector Control Approaches for Canine Filariasis
Wolbachia Endosymbionts as Treatment Targets for Filarial Diseases
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