Small Animal Imaging 2nd Edition

Small Animal Imaging 2nd Edition PDF

By Fabian Kiessling and Bernd J. Pichler

Small Animal Imaging 2nd Edition PDF is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

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Table of Contents

Front Matter

Role of Small Animal Imaging

Noninvasive Imaging for Supporting Basic Research

Non-Invasive Imaging in the Pharmaceutical Industry

How to Set Up a Small Animal Imaging Unit

Noninvasive Small Rodent Imaging: Significance for the 3R Principles

Study Planning and Animal Preparation

Institutional Preconditions for Small Animal Imaging

Statistical Considerations for Animal Imaging Studies

Animal Anesthesia and Monitoring

Drug Administration

Imaging Modalities and Probes

How to Choose the Right Imaging Modality

X-Ray and X-Ray-CT

CT Contrast Agents

Small Animal Magnetic Resonance Imaging: Basic Principles, Instrumentation and Practical Issue

MR Contrast Agents

MR Spectroscopy


Ultrasound Contrast Agents


Radiotracer I: Standard Tracer

Radiotracer II: Peptide-Based Radiopharmaceuticals

Optical Imaging

Optical Probes

Multi-modal Imaging and Image Fusion

Ex Vivo Validation Methods

Ex Vivo and In Vitro Cross Calibration Methods

In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting

Data Postprocessing

Qualitative and Quantitative Data Analysis

Guidelines for Nuclear Image Analysis

Kinetic Modelling

Data Documentation Systems

Special Applications

Imaging in Developmental Biology

Imaging in Gynecology Research

Imaging in Cardiovascular Research

Imaging in Neurology Research I: Neurooncology

Imaging in Neurology Research II: PET Imaging of CNS Disorders

Imaging in Neurology Research III: Focus on Neurotransmitter Imaging

Imaging in Oncology Research

Imaging in Immunology Research


Erratum to: In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting

Back Matter

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