Mirtazapine In Dogs & Cats: Uses, Dosage and Side Effects
Overview
- Tricyclic antidepressant acts on central alpha-2 receptors which leads to increased noradrenaline levels within the brain.
- Also inhibits several types of serotonin receptors and histamine (H1) receptors.
Uses of Mirtazapine
- Appetite stimulation in dogs and cats.
- Efficacy in cats with stable chronic kidney disease has been demonstrated.
- Antiemetic role in conjunction with other drugs, but authorized preparations should be used.
- Anecdotal use beginning to appear concerning its use in the management of social fears in dogs.
Dose of Mirtazapine in Dogs and Cats
Dogs:
- 1.1–1.3 mg/kg p.o. q24h.
Cats:
- 1.9 mg/cat p.o. q48h (can double dose if needed or increase frequency to q24h but not both).
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Side Effects of Mirtazapine in Dogs and Cats
- Sedation is common and can be profound.
- Can affect behaviour in many different ways, increased vocalization and interaction with others.
- Has been associated with blood dyscrasias in humans.
Contraindications of Mirtazapine in Dogs and Cats
- Do not use in patients with pre-existing haematological disease.
Some Notes:
- Several interactions are known in humans, principally involving other behaviour-modifying drugs.
- Monitor animals carefully when using mirtazapine, particularly if there is also cardiac, hepatic or renal disease.
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