Sucralfate

Sucralfate In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• In an acidic medium, aluminum ion detachment occurs from the compound.
• The detached ion is very polar and relatively non-absorbable.
• This ion binds to proteinaceous exudates in the upper GI tract.
• Forms a chemical diffusion barrier over ulcer sites, preventing further erosion from acid, pepsin, and bile salts.
• Major action involves stimulating mucosal defenses and repair mechanisms.
• Stimulation includes bicarbonate and PGE production and binding of epidermal growth factor.
• These effects are observed at neutral pH.

Uses of Sucralfate

• Treatment of oesophageal, gastric and duodenal ulceration.
• The efficacy of sucralfate as a phosphate binder in renal failure is uncertain.
• Can be used alongside an H2 receptor antagonist or proton-pump inhibitor but should be given separately.

Dose of Sucralfate in Dogs and Cats

Dogs:

• All uses: 500 mg/dog p.o. q6–8h (dogs up to 20 kg); 1–2 g/ dog p.o. q6–8h (>20 kg).

Cats:

• All uses: 250 mg/cat p.o. q8–12h.

Side Effects of Sucralfate in Dogs and Cats

• Minimal; constipation is the main problem in humans.
• Bezoar formation and hypophosphataemia are also reported in humans.

Contraindications of Sucralfate in Dogs and Cats

• Perforated ulcer.

Some Notes:

• Sucralfate may decrease the bioavailability of H2 antagonists, phenytoin and tetracyclines.
• It may be a wise precaution to administer sucralfate at least 2 hours before or after
  these drugs.
• Sucralfate interferes significantly with the absorption of fluoroquinolones and digoxin.