Indoxacarb

Indoxacarb Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Acts on voltage-dependent sodium channels in susceptible insects.

Uses of Indoxacarb

• Treatment of flea infestations (Ctenocephalides felis).

Dose of Indoxacarb in Dogs and Cats

Dogs:

• Fleas: 15 mg/kg (equivalent to 0.077 ml/kg Activyl or 0.1 ml/ kg Activyl Tick Plus).
• Apply monthly.

Cats:

• Fleas: 25 mg/kg (equivalent to 0.128 ml/kg Activyl).
• Apply monthly.
• The combined formulation is not authorized for cats.

Side Effects of Indoxacarb in Dogs and Cats

• Transient pruritus at the site of application can occur.
• Rarely GI signs.

Contraindications of Indoxacarb in Dogs and Cats

• Do not use on dogs and cats <8 weeks old or on dogs <1.5 kg (<1.2 kg Activyl plus) or on cats <0.6 kg.
• Do not use permethrin products on cats

Some Notes:

• Flea larvae in the local area are killed upon touch.
• Indoxacarb is highly selective for insect cells since it is a pro-drug bioactivated by insect enzymes and the active component has a considerably higher affinity for insect sodium channels.
• Fleas in their developing stages in the treated pet’s immediate environment are killed on touch.
• Permethrin-containing formulations also protect against tick infestations (Ixodes ricinus and Rhipicephalus sanguineus).
• Ticks may not be killed within 48 hours if they are present on the dog at the time of application.