Pyriprole

Pyriprole In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Interaction with ligand-gated (GABA) chloride channels, blocking the pre-and post-synaptic transfer of chloride ions, leads to death of parasites.

Uses of Pyriprole

• Treatment and prevention of flea infestations (Ctenocephalides canis, C. felis) and tick prevention in dogs >8 weeks and >2 kg.
• When treating flea infestations, it is advisable to use an approved insect growth regulator in addition to the treatment.
• For larger dogs, the recommended application is 5 ml, which should be distributed in 2 to 3 separate spots on the dog’s body.
• It’s important to avoid bathing the dog for 48 hours before and 24 hours after the application to ensure the effectiveness of the treatment.

Dose of Pyriprole in Dogs and Cats

Dogs:

• Fleas and ticks: minimum dose 12.5 mg/kg topically q4wk.

Cats:

• Do not use.

Side Effects of Pyriprole in Dogs and Cats

• Pruritus/dermatitis at application site, lethargy, ataxia, convulsions, emesis, diarrhoea.

Contraindications of Pyriprole in Dogs and Cats

• Safety has not been established in pregnant and lactating females.
• Do not use it on cats.

Some Notes: