Sarolaner

Sarolaner In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Sarolaner acts at ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes.

Uses of Sarolaner

• The product is used for the treatment of fleas, ticks, and ear mite infestations (Otodectes cynotis) in dogs and cats, as well as demodicosis (Demodex canis) and Sarcoptes scabiei in dogs.
• It is also effective against biting lice (Felicola subrostratus), adult roundworms (Toxocara cati), and adult intestinal hookworms (Ancylostoma tubaeforme) when applied topically for cats.
• The product requires parasites to start feeding on the host for exposure to sarolaner. Therefore, it cannot exclude the potential transmission of infectious parasite-borne diseases during this process.
• Additionally, the product is used for the prevention of heartworm disease caused by Dirofilaria immitis in dogs and cats

Dose of Sarolaner in Dogs and Cats

Dogs:

• 2–4 mg/kg.
• Administer every month.

Cats:

• 6 mg/kg selamectin and 1 mg/kg sarolaner.
• Administer monthly.

Side Effects of Sarolaner in Dogs and Cats

• Mild GI signs may occur.
• Mild pruritus at site of application of spot-on product.

Contraindications of Sarolaner in Dogs and Cats

• Do not use in dogs <8 weeks or <1.3 kg.
• Do not use in cats <8 weeks old or <1.25 kg.

Some Notes:

• Sarolaner is highly bound to plasma proteins and might compete with other highly bound drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and the cumarin
  derivative warfarin.
• No interactions were observed when sarolaner was co-administered with milbemycin oxime, moxidectin and pyrantel pamoate.