Fipronil

Fipronil: Uses, Dosage and Side Effects

Overview

• Fipronil interacts with ligand-gated (GABA) chloride channels, preventing the pre-and post-synaptic transfer of chloride ions and causing parasite death on contact.

Uses of Fipronil

• Insecticidal and acaricidal activity against fleas (Ctenocephalides spp. ), ticks (Rhipicephalus spp., Dermacentor spp., Ixodes spp. ), and feline and canine lice (Felicola subrostratus, Trichodectes canis).
• May contribute to the management of Neotrombicula autumnalis, Sarcoptes spp., and Cheyletiella spp.

Dose of Fipronil in Dogs and Cats

Dogs:

• Flea infestations: spray 3–6 ml/kg (6–12 pumps/kg 100 ml application, 2–4 pumps/kg 250 ml or 500 ml application) or apply 1 pipette per dog according to body weight.
• Treatment should be repeated not more frequently than every 4 weeks
• Neotrombicula autumnalis, Sarcoptes spp. and Cheyletiella spp. infestations: spray should be used every 1–2 weeks.

Cats:

• Spray 3–6 ml/kg (6–12 pumps/kg 100 ml application) or apply 1 pipette per cat.
• Treatment should be repeated monthly.

Side Effects of Fipronil in Dogs and Cats

• Local pruritus or alopecia may occur at the site of application.

Contraindications of Fipronil in Dogs and Cats

• Fipronil spot-on: do not use in dogs and cats <8 weeks of age and <2 kg (dogs) or <1 kg (cats).
• Fipronil spray: may be used in puppies and kittens from 2 days old.
• Fipronil may be harmful to aquatic organisms.
• Do not use fipronil, S-methoprene, eprinomectin and praziquantel combination (Broadline) in dogs.

Some Notes:

• Effective against flea infestation for approximately 2 months and against tick infestations for up to 1 month.
• Bathing between 48 hours before and 24 hours after application is not recommended.
• Can be used in pregnant and lactating females.
• When treating flea infestations, treatment of the environment is also recommended.