Dexrazoxane

Dexrazoxane: Uses, Dosage and Side Effects

Overview

• Prevents the formation of anthracycline-iron complex free radicals thought to be the cause of anthracycline-induced cardiotoxicity and extravasation reactions.

Uses of Dexrazoxane

• Manage complications associated with the use of anthracycline chemotherapeutics.

Dose of Dexrazoxane in Dogs and Cats

Dogs:

• Extravasation injury:
• Terminate doxorubicin infusion and administer 1000 mg/m2 i.v. into a separate infusion (ideally within 6 hours).
• Repeat on day 2 (1000 mg/m2 i.v.) and day 3 (500 mg/ m2 i.v.).
• Lower doses have also been shown to be effective (250–500 mg/m2 i.v.).
• Prevention of doxorubicin cardiotoxicity:
• 10 minutes before doxorubicin 10 times the administered milligram dose of doxorubicin i.v. over 5–10 minutes.

Cats:

Unknown.

Side Effects of Dexrazoxane in Dogs and Cats

• Myelosuppression is documented in humans.
• It may also decrease the clinical efficacy of anthracycline anti-neoplastic agents.

Contraindications of Dexrazoxane in Dogs and Cats

unknown