Tylosin

Tylosin In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• A time-dependent macrolide antibiotic that binds to the 50S ribosomal subunit, suppressing bacterial protein synthesis.

Uses of Tylosin

• Tylosin exhibits strong activity against mycoplasmas and shares a similar antibacterial spectrum with erythromycin.
• However, it is generally less effective against bacteria compared to erythromycin.
• While seldom prescribed in small animal medicine, it has been utilized for treating antibiotic-responsive diarrhoea in dogs and for cryptosporidiosis.
• Administration in dogs and cats is mainly done orally.

Dose of Tylosin in Dogs and Cats

Dogs:

• Various doses: 7–15 mg/kg p.o. q12–24h.
• In colitis, higher doses are recommended 12–20 mg/kg q8h with food gradually increasing the dosing interval to q24h.

Cats:

• 7–15 mg/kg p.o. q12–24h.

Side Effects of Tylosin in Dogs and Cats

• Tylosin can lead to gastrointestinal disturbances.
• Its effectiveness is increased in an alkaline pH environment.
• Injection of tylosin may cause pain at the injection site.

Contraindications of Tylosin in Dogs and Cats

• No information is available.

Some Notes:

• Not well documented in small animals.
• It does not appear to inhibit the same hepatic enzymes as erythromycin.