Fomepizole (4-Methylpyrazole)

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Fomepizole (4-Methylpyrazole): Uses, Dosage and Side Effects

Fomepizole (4-Methylpyrazole): Uses, Dosage and Side Effects

Overview

  • Competitive inhibition of alcohol dehydrogenase.

Uses of Fomepizole (4-Methylpyrazole)

  • Treatment of ethylene glycol (antifreeze) toxicity in dogs.
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Dose of Fomepizole (4-Methylpyrazole) in Dogs and Cats

Dogs:

  • Ethylene glycol toxicity: 20 mg/kg i.v. infusion over 30 min initially, then 15 mg/kg i.v. slowly over 15–30 min 12 h and 24 h later, then 5 mg/kg i.v. q12h until ethylene glycol concentration is negligible or the dog has recovered.
  • Most effective if started within 8 hours of intoxication.

Cats:

  • Ethylene glycol toxicity: 125 mg/kg slow i.v. then 31.25 mg/kg i.v. q12h for 3 additional doses.
  • Efficacy has been shown if treated within 3 hours of ingestion.

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Side Effects of Fomepizole (4-Methylpyrazole) in Dogs and Cats

  • No information is available.

Contraindications of Fomepizole (4-Methylpyrazole) in Dogs and Cats

  • No information is available.

Some Notes:

  • Increases risk of ethanol toxicity if co-administered.
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