Aglepristone for Dogs, Cats, Sheep, and Rabbits: Dosage, Uses, and Side Effects Guide
Overview
An injectable solution, its action depends on the elimination of progesterone support for up to 7 days resulting from blocking progesterone receptors.
Uses of Acetylcysteine
- Dogs:
- Pregnancy termination up to 45 days post-mating.
- Treatment of pyometra (often combined with prostaglandin F analogs).
- Induction of parturition when combined with oxytocin.
- Treatment of insulin-resistant diabetes mellitus in intact bitches (alternative to ovariectomy).
- Management of benign vaginal tumors.
- Control of progesterone receptor-positive mammary carcinomas.
- Cats:
- Pregnancy termination (efficacy improves with misoprostol or cabergoline).
- Treatment of fibroadenomatous mammary hyperplasia.
- Management of pyometra with concurrent antibiotic therapy.
- Sheep:
- Parturition induction and treatment of pregnancy toxemia.
- Rabbits:
- Prevention of fetal implantation when administered early.
Dose of Aglepristone For Dogs, Cats, Sheep, and Rabbits
Below are specific doses of Aglepristone for various conditions and species:
| Species | Condition Treated with Aglepristone | Dosage |
|---|---|---|
| Dogs | Pregnancy termination (up to day 45) | 10 mg/kg SC, repeated after 24 hours |
| Pyometra | 10 mg/kg SC on days 1, 2, and 7; additional doses on days 14 and 21 if needed | |
| Progesterone-induced acromegaly | 10 mg/kg SC every 7 days for three doses | |
| Insulin-resistant diabetes mellitus | 10 mg/kg SC on days 1, 2, 9, and 17 during the luteal phase, with PZI insulin | |
| Benign vaginal tumors | 10 mg/kg SC on days 1, 2, 8, 15, 28, and 35 | |
| Mammary carcinomas (progesterone receptor-positive) | 20 mg/kg SC on days 1, 8, and 15 | |
| Cats | Pregnancy termination | 15 mg/kg SC every 24 hours for two doses |
| Mammary fibroadenomatous hyperplasia | 20 mg/kg SC every 7 days | |
| Sheep | Parturition induction | 5–10 mg/kg SC for two consecutive days |
| Rabbits | Prevention of fetal implantation | 10 mg/kg SC twice, 24 hours apart |
Drug Dosage Calculator
You Should Give:
Side Effects of Aglepristone For Dogs, Cats, Sheep, and Rabbits
- Local injection site reactions (pain, swelling, edema, skin thickening).
- Gastrointestinal symptoms (anorexia, diarrhea).
- Uterine infections (rare).
- Tachycardia reported in cats.
- Brown mucoid discharge 24 hours before fetal expulsion during pregnancy termination.
Contraindications of Aglepristone For Dogs, Cats, Sheep, and Rabbits
- Avoid use in animals with suspected hypoadrenocorticism.
- Not recommended for animals with hepatic or renal impairment.
- Contraindicated in animals with chronic obstructive airway disease or cardiovascular conditions.
Some Notes:
- Injection Handling: Administer no more than 5 ml per injection site. Use the scruff of the neck for injection and massage the site after administration to prevent reactions.
- Pregnancy Termination Considerations:
- When used after day 20 of pregnancy, physiological signs of parturition may occur, including mammary congestion and lactation.
- Drug Interactions:
- Concurrent use with glucocorticoids may reduce the efficacy of each drug.
- Interaction with azole antifungals (e.g., ketoconazole) is possible due to inhibition of CYP3A pathways
- Monitoring:
- Monitor pregnancy termination with ultrasonography 10 days after treatment.
- Evaluate for signs of pyometra resolution via physical exam and bloodwork.
- Human Safety: This product must not be handled by pregnant women due to the risk of accidental abortion.
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