By Jerald Silverman, Mark A. Suckow and Sreekant Murthy
Ever since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. As biomedical research continuously grows, the role and impact of the IACUC has increased in scope and complexity. The IACUC Handbook has become “the Bible” for individuals when the time comes for them to serve on their institution’s IACUC. It provides a foundation for understanding and implementing the many and varied responsibilities of this committee.
This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use of Laboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and theOffice of Laboratory Animal Welfare’s Frequently Asked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wisdom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews can function in other countries.
Introduction to the Third Edition Patricia A. Brown and Chester A. Gipson
Origins of the IACUC Harry Rozmiarek
Circumstances Requiring an IACUC Marcy Brown and Mary Jo Shepherd
Creation of an IACUC Marcy Brown and Mary Jo Shepherd
Reporting Lines of the IACUC Marcy Brown and Mary Jo Shepherd
General Composition of the IACUC and Specific Roles of the IACUC Members Christian E. Newcomer and William G. Greer
Frequency and Conduct of Regular IACUC Meetings Sreekant Murthy
General Format of IACUC Protocol Forms Christian E. Newcomer and William G. Greer
Submission and Maintenance of IACUC Protocols Kathy Laber and Alison C. Smith
General Concepts of Protocol Review Ernest D. Prentice, Gwenn S. F. Oki, and Michael D. Mann
Amending IACUC Protocols Angela M. Mexas and Diane J. Gaertner
Continuing Review of Protocols Gwenn S.F. Oki and Ernest D. Prentice
Justification for the Use of Animals Larry Carbone
Justification of the Number of Animals to Be Used Ed J. Gracely
Animal Acquisition and Disposition Michael J. Huerkamp, Larry Iten, and David R. Archer
Animal Housing, Use Sites, and Transportation Robert M. Bigsby and Robin Crisler-Roberts
Pain and Distress Alicia Z. Karas and Jerald Silverman
Euthanasia Peggy J. Danneman
Surgery Lester L. Rolf, Jr.
Antigens, Antibodies, and Blood Collection Harold F. Stills, Jr.
Occupational Health and Safety Robin Lyn Trundy and Susan Stein Cook
Personnel Training Howard G. Rush and Melissa C. Dyson
Confidential and Proprietary Information Marilyn J. Chimes and Priya Sankar
General Concepts of the Program Review and Facility Inspection Joseph D. Thulin and Kenneth P. Allen
Inspection of Animal Housing Areas Christine A. Boehm and Debra L. Hickman
Inspection of Individual Laboratories Neil S. Lipman and Scott E. Perkins
Inspection of Surgery Areas Scott E. Perkins and Neil S. Lipman
Assessment of Veterinary Care Mark A. Suckow and Bernard J. Doerning
Laboratory Animal Enrichment Kathryn Bayne and Jennifer N. Camacho
Animal Mistreatment and Protocol Noncompliance Jerald Silverman
Postapproval Monitoring Ron E. Banks
The European Ethical Review Framework: Collaborative Issues Javier Guillén
