Pathology of Genetically Engineered and Other Mutant Mice
By John P. Sundberg , Peter Vogel , Jerrold M. Ward
Pathology of Genetically Engineered and Other Mutant Mice PDF delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.
The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.
Readers will also benefit from:
A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice
An exploration of concepts related to validating animal models, including the Cinderella Effect
Practical discussions of basic necropsy methods and grading lesions for computational analyses
Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues
As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
Table of Contents
Contributors List
Preface and Acknowledgements
Chapter 1. Introduction to Mouse Pathology Jerrold M. Ward, Peter Vogel, John P. Sundberg
Chapter 2. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research Dale A. Begley, Paul N. Schofield, and John P. Sundberg
Chapter 3. Mouse Genetic Nomenclature; the Underpinning of Mouse Genetics John P. Sundberg, Dale Begley, Melissa Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield
Chapter 4. Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofiel
Chapter 5. Embryos, Placentas, and Neonates Brad Bolon and Jerrold M. Ward
Chapter 6. Ciliopathies Peter Vogel and Laura L. Janke
Chapter 7. Hematopoietic and Lymphoid Tissues Harm HogenEsch and John P. Sundberg
Chapter 8. Hematolymphoid Neoplasms Jerold E. Rehg
Chapter 9. Immunodeficient and Humanized Mice Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch
Chapter 10. Skin, Hair, and Nails John P. Sundberg, Lloyd E. King, Jr., Raoul V. Kuiper
Chapter 11. Mammary Gland Alexander D. Borowsky and Robert D. Cardiff
Chapter 12. Respiratory System Jerry M. Ward and John P. Sundberg
Chapter 13. Gastrointestinal Tract Jerrold M. Ward, Piper M. Treuting, M. Kay Washington
Chapter 14. Cardiovascular System Kathleen Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy Cooper
Chapter 15. Liver and Pancreas Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger
Chapter 16. Neuromuscular System Peter Vogel, Laura L. Janke, and Heather S. Tillman
Chapter 17. Endocrine System Krista Marie DuBray La Perle
Chapter 18. Kidney and Urinary Bladder Jeffrey B. Kopp, Cory F. Brayton, Jeffrey Everett, Avi Z. Rosenberg, Jerrold M. Ward
Chapter 19. Female Reproductive Tract Darlene Dixon and Alexander Nikitin
Chapter 20. Male Reproductive Tract Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, Robert D. Cardiff
Chapter 21. Nervous System Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli
Chapter 22. Eye and Ear Heather Tillman, Laura Janke, Jerold Rehg, Peter Vogel
Chapter 23. Bones and teeth Peter Vogel, John P. Sundberg, Cheryl Ackert-Bicknell
