Cell and Molecular Biology of the Cytoskeleton PDF focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and others. Intermedi ate filaments consist of at least five different tissue-specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). In this volume distinguished researchers in the field cover the interaction of these fibrous proteins, not only with each other and other cytoplasmic components, but also with such biological processes as cell shape changes, growth, motility, secretion, and division. These comprehensive reviews ex plore the cytoskeleton’s molecular, biochemical, and structural properties with an emphasis on their manifestation in the living cell.
Table of Contents
Front Matter
Probing the Cytoskeleton by Microinjection
Structural Aspects of Intermediate Filaments
The Structure and Evolution of Intermediate Filament Genes
Differential Expression of the Genes Encoding the Keratins of Cultured Human Epidermal Cells
Organization and Expression of the Vimentin and Desmin Genes
Actin
The Actin Genes in Caenorhabditis elegans
Implications of Microtubule Polarity for Microtubule Function
