Series Editors
Contributors
Chapter One. Molecular Insights into Intracellular RNA Localization
1. Introduction
2. Extent and Locations of mRNA Localization
3. Mechanisms of mRNA Localization
4. Motor-Driven Directed Transport of Localization-Competent mRNPs
5. Formation and Structure of RNA Granules
6. Regulation and Roles of Localized mRNAs
7. Perspective
References
Chapter Two. A Hypothesis on the Origin and Evolution of Tubulin
Abbreviations
1. Introduction
2. Tubulin Isotypes
3. Evolution of the Tubulin/FtsZ Superfamily
4. The Origin of the C-terminal Tail of Tubulin: Back before the Beginning?
5. Experimental Tests of These Hypotheses
6. Concluding Remarks
References
Chapter Three. Dynamin: Expanding Its Scope to the Cytoskeleton
1. Introduction
2. DynaminโA Membrane Remodeling GTPase
3. Actions of Dynamin and Actin Filaments during Endocytosis
4. Beyond Endocytosis: Dynamin as a Cytoskeletal Regulator
5. Dynamin Mutations, Cytoskeleton and Human Disease
6. Concluding Remarks
References
Chapter Four. Beta-Barrel Scaffold of Fluorescent Proteins: Folding, Stability and Role in Chromophore Formation
1. Introduction
2. Chromophore Formation and Transformations in Fluorescent Proteins
3. Structure of Fluorescent Proteins and Their Unique Properties
4. Pioneering Studies of Fluorescent Protein Stability
5. Unfoldingโrefolding of fluorescent proteins
6. Concluding Remarks
References
Chapter Five. Cytoskeletal Proteins: Shaping Progression of Hepatitis C Virus-Induced Liver Disease
1. Introduction
2. Overview of HCV
3. Pathology of Acute to CHC with Emphasis on Cs Changes
4. Role in HCV Infection and Pathogenesis
5. Summary and Key Question for Future Research
References
Chapter Six. Integrins and Small GTPases as Modulators of Phagocytosis
Abbreviations
1. Introduction
2. Integrins as Phagocytic Receptors
3. Biological Implications: Phagocytic Integrins and Apoptotic Cell Clearance
4. Integrin-Dependent Phagocytic Tissue Remodeling
5. Role of Phagocytosis in Tissue Maintenance and Homeostasis
6. Integrin-Dependent Phagocytosis and Pathogenesis
7. Conclusions and Perspectives
References
Index