Contributors xiiiPreface xix
About the Companion Website xxi
Section 1 Principles of Pharmacology 1
1 Veterinary Pharmacology: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich
2 Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere
3 Pharmacokinetics 41
Jim E. Riviere
4 Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain
5 Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez
Section 2 Drugs Acting on the Autonomic Nervous System 111
6 Introduction to the Autonomic Nervous System and Autonomic Pharmacology 113
Joshua A. Rowe, Rose M. McMurphy, Barbara J. Lutjemeier, and Michael J. Kenney
7 Adrenergic Receptor Agonists and Antagonists 131
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and ;Michael J. Kenney
8 Cholinergic Pharmacology: Autonomic Drugs 151
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Marjory A. Artzer, Barbara J. Lutjemeier, and Michael J. Kenney
Section 3 Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165
9 Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey
10 Neuromuscular Blocking Agents 194
Diane E .Mason and Christopher L. Norkus
11 Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey
12 Injectable Anesthetic Agents 247
Lysa P. Posner
13 Opioid Analgesic Drugs 281
Butch KuKanich and Mark G. Papich
14 Sedatives and Tranquilizers 324
Lysa P. Posner
15 Local Anesthetics 369
Thomas W. Vickroy
16 Euthanizing Agents 387
Anna Hampton
17 Anticonvulsant Drugs 395
Mark G. Papich
18 Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich
Section 4 Autacoids and Antiinflammatory Drugs 449
19 Histamine, Serotonin, and their Antagonists 451
Wolfgang Baumer
20 Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees
Section 5 Drugs Acting on the Cardiovascular System 501
21 Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames
22 Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere
Section 6 Drugs Affecting Renal Function and Fluid–Electrolyte Balance 553
23 Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar
24 Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar
Section 7 Drugs Acting on Blood and Blood Elements 623
25 Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich
Section 8 Endocrine Pharmacology 647
26 Hypothalamic and Pituitary Hormones 649
Srujana Rayalam, Margarethe Hoenig, and Duncan C. Ferguson
27 Hormones Affecting Reproduction 674
Wolfgang Baumer, C. Scott Bailey, and John Gadsby
28 Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson
29 Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
Duncan C. Ferguson and Margarethe Hoenig
30 Drugs Influencing Glucose Metabolism 763
Margarethe Hoenig
Section 9 Chemotherapy of Microbial Diseases 779
31 Antiseptics and Disinfectants 781
Megan E. Jacob
32 Sulfonamides and Potentiated Sulfonamides 796
Mark G. Papich
33 𝛃-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
Mark G. Papich
34 Tetracycline Antibiotics 858
Mark G. Papich and Jim E. Riviere
35 Aminoglycoside Antibiotics 877
Mark G. Papich and Jim E. Riviere
36 Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 903
Mark G. Papich
37 Fluoroquinolone Antimicrobial Drugs 953
Mark G. Papich
38 Antifungal and Antiviral Drugs 988
Jennifer L. Davis and Lara Maxwell
Section 10 Chemotherapy of Parasitic Diseases 1033
39 Antinematodal Drugs 1035
Carlos E. Lanusse, Juan M. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez
40 Anticestodal and Antitrematodal Drugs 1081
Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel
41 Macrocyclic Lactones: Endectocide Compounds 1102
Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz
42 Antiprotozoan Drugs 1128
Jennifer L. Davis and Jody L. Gookin
43 Ectoparasiticides 1166
Ronald E. Baynes
Section 11 Specialty Areas of Pharmacology 1189
44 Chemotherapy of Neoplastic Diseases 1191
Luke A.Wittenburg and Daniel L. Gustafson
45 Immunosuppressive Drugs 1226
Mark G. Papich
46 Drugs for Treating Gastrointestinal Diseases 1245
Mark G. Papich
47 Dermatopharmacology: Drugs Acting Locally on the Skin 1278
Jim E. Riviere and Rosanna Marsella
48 Drugs that Affect the Respiratory System 1302
Mark G. Papich
49 Ophthalmic Pharmacology 1321
Alison Clode
50 Pharmacogenomics 1332
Katrina L. Mealey
51 Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1345
Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring
52 Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
Michael D. Apley
53 Pharmacology in Aquatic Animals 1373
Ron A. Miller
54 Zoological Pharmacology 1395
Robert P. Hunter
Section 12 Regulatory and Other Considerations 1405
55 The Regulation of Animal Drugs 1407
Steven D. Vaughn and Marilyn N. Martinez
56 Veterinary Pharmacy 1427
Gigi Davidson and Mark G. Papich
57 Medication Control Programs in Performance Animals 1439
Cynthia A. Cole
58 Pharmacovigilance 1448
John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer
59 Dosage Forms and Veterinary Feed Directives 1459
Geof Smith and Jim E. Riviere
60 Evidence-Based Pharmacotherapy 1465
Ronette Gehring
61 Chemical Residues in Tissues of Food Animals 1469
Jim E. Riviere
Index 1481
