Ganciclovir

Ganciclovir: Uses, Dosage and Side Effects

Overview

• Inhibits viral replication (viral DNA polymerase); depends on viral thymidine kinase for phosphorylation.

Uses of Ganciclovir

• Management of ocular feline herpesvirus-1 (FHV-1) infections.

Dose of Ganciclovir in Dogs and Cats

Dogs:

• No information available.

Cats:

• Apply small amount to affected eye q4–6h (maximum 3 weeks).

Side Effects of Ganciclovir in Dogs and Cats

• Ocular irritation may occur and the frequency of application should be reduced if this develops.
• Treatment should not be continued for >3 weeks

Contraindications of Ganciclovir in Dogs and Cats

• No information available.

Some Notes:

• In vitro studies show that ganciclovir is at least 10 times more effective against FHV-1 than aciclovir.
• Anecdotal reports of its topical use are promising, but neither the safety nor the pharmacokinetics has been reported in cats.
• Cannot eradicate latent viral infection.
• In refractory and severe cases of FHV-1 ulceration, combined therapy, including topical or systemic antiviral medication can be used.