Miltefosine

Miltefosine In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Directly toxic to Leishmania and also enhances T cell and macrophage activation.

Uses of Miltefosine

• Treatment of canine leishmaniosis leads to a substantial reduction in the parasitic load without complete elimination (similar to other treatment strategies).

Dose of Miltefosine in Dogs and Cats

Dogs:

• Leishmaniosis: 2 mg/kg p.o. q24h for 28 days (it is particularly important that the full course is completed and given with allopurinol).

Cats:

• No information is available.

Side Effects of Miltefosine in Dogs and Cats

• Moderate and transient vomiting and diarrhoea are very common and can last up to 7 days.
• The side effects do not affect the efficacy of the product and do not require
  discontinuation of treatment or dose change.
• Overdoses may produce uncontrollable vomiting.

Contraindications of Miltefosine in Dogs and Cats

• Do not use during pregnancy, lactation or in breeding animals.

Some Notes:

• Nearly as effective as the allopurinol/meglumine antimonate protocol with fewer serious side effects.
• A Special Treatment Authorization is required to obtain this product (it is authorized for veterinary use in Spain and Germany).
• It is recommended to pour the product on to the animal’s feed to reduce digestive side effects.
• Allopurinol is recommended as an adjunctive treatment and should be continued
  after the course of miltefosine is complete.