Nicotinamide (Niacinamide, Vitamin B3)

Nicotinamide (Niacinamide, Vitamin B3) In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Blocks antigen-induced histamine release.
• Inhibits phosphodiesterase activity and protease release.

Uses of Nicotinamide (Niacinamide, Vitamin B3)

• Has been used in combination with oxytetracycline/ tetracycline or doxycycline in the management of certain immune-mediated dermatoses such as lupoid onychodystrophy, discoid lupus erythematosus and pemphigus foliaceus.

Dose of Nicotinamide (Niacinamide, Vitamin B3) in Dogs and Cats

Dogs:

Immunomodulation:

• 250 mg/dog q8h (dogs up to 25 kg)
• 500 mg/dog q8h (dogs >25 kg).
• Taper to effect.

Cats:

• No information is available.

Side Effects of Nicotinamide (Niacinamide, Vitamin B3) in Dogs and Cats

• May cause mild GI irritation.

Contraindications of Nicotinamide (Niacinamide, Vitamin B3) in Dogs and Cats

• Do not use nicotinic acid (niacin) as it causes vasodilation.