Brinzolamide

Brinzolamide: Uses, Dosage and Side Effects

Overview

• Reduces intraocular pressure by reducing the rate of aqueous humour production by inhibiting the formation of bicarbonate ions within the ciliary body epithelium.

Uses of Brinzolamide

• In the control of all types of glaucoma in dogs, either alone or in combination with other topical drugs.
• It may be better tolerated than dorzolamide because of its more physiological pH of 7.5.
• Brinzolamide is ineffective in normal cats but may reduce IOP in glaucomatous cats; by contrast, dorzolamide is effective in both dogs and cats.

Dose of Brinzolamide in Dogs and Cats

Dogs, Cats:

1 drop/eye q8–12h.

Side Effects of Brinzolamide in Dogs and Cats

• Local irritation, keratitis, blepharitis.
• Brinzolamide may cause less ocular irritation than dorzolamide.
• Timolol can cause bradycardia and hypotension.
• Rarely, carbonic anhydrase inhibitors have been reported to cause hypokalaemia in cats, and metabolic acidosis in dogs, as a result of systemic absorption.

Contraindications of Brinzolamide in Dogs and Cats

• Severe hepatic or renal impairment.
• Timolol causes miosis and is therefore not the drug of choice in uveitis, anterior lens luxation or pupil block.