Clofazimine

Clofazimine: Uses, Dosage and Side Effects

Overview

• Not entirely clear but appears to be antimycobacterial and has membrane-disrupting properties.

Uses of Clofazimine

• Mycobacterial infections including feline leprosy.
• For feline mycobacterial infection, long-term treatment is required and combination therapy is utilized, e.g. with clarithromycin and doxycycline or fluoroquinolones.

Dose of Clofazimine in Dogs and Cats

Dogs, Cats:

• 4–8 mg/kg p.o. q24h for 2–6 months.
• For the management of mycobacterial infections, the drug is generally used in combination therapy with other antimicrobials including fluoroquinolones and clarithromycin.

Side Effects of Clofazimine in Dogs and Cats

• Photosensitization can occur and treated animals should be housed indoors.
• Diarrhea, discoloration of skin, eyes, and body fluids, and renal and hepatic impairment may develop.

Contraindications of Clofazimine in Dogs and Cats

No information is available.

Some Notes:

• Monitor hepatic and renal function during treatment.
• Use with caution in hepatic and renal impairment.