Ticarcillin

Ticarcillin In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Time-dependent, beta-lactam antibiotic.
• Binds to penicillin-binding proteins, disrupting cell wall synthesis.
• Reduces bacterial cell wall strength and rigidity, affecting cell division, growth, and septum formation.
• Clavulanic acid serves as a non-competitive ‘suicide’ inhibitor for beta-lactamase enzymes.

Uses of Ticarcillin

• Carboxypenicillin is indicated for treating serious infections caused by Pseudomonas aeruginosa and other Gram-negative bacteria like Proteus spp. and Bacteroides fragilis.
• Often used with an aminoglycoside (e.g., gentamicin) for Pseudomonas septicaemias due to synergistic effect.
• Kills bacteria via a time-dependent mechanism, requiring dosing regimens to maintain tissue concentration above the MIC throughout the interdosing interval.
• Limited pharmacokinetic data is available for the ticarcillin/clavulanic acid combination in veterinary species.
• Stability after reconstitution varies depending on the diluent used.

Dose of Ticarcillin in Dogs and Cats

Dogs, Cats:

• For serious systemic infections: 15–25 mg/kg i.v., followed by CRI at 7.5–15 mg/kg/h; topical to the ear as an adjunct to Pseudomonas otitis, instil 0.25–0.5 ml of a 100 mg/ml injectable ticarcillin solution into the affected ear q8h.

Side Effects of Ticarcillin in Dogs and Cats

• Nausea, diarrhoea and skin rashes may be seen.

Contraindications of Ticarcillin in Dogs and Cats

• No information available.

Some Notes:

• Do not mix with aminoglycosides in the same syringe because there is mutual inactivation.
• There is synergism in vivo between the beta-lactams and the aminoglycosides.