Pyrantel Parasiticide Therapy in Humans and Domestic Animals
By Alan Marchiondo
Pyrantel Parasiticide Therapy in Humans and Domestic Animals PDF presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes.
Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970’s to control two important nematode groups, the hookworms and the roundworms.
Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.
Easy-to-use reference guide on the anthelmintic pyrantel for clinicians, parasitologists, and researchers in human and veterinary medicine
Addresses current issues of resistance, along with combination uses against anthelmintic resistant parasites
Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds
Includes a discussion on pyrantel’s potential role in combination therapies
Provides cutting-edge material, and will be an evolving area of scientific discussion of treatment options in the future
List of Contributors
Preface
Introduction Chapter 1. Discovery and Chemistry of Pyrantel, Morantel and Oxantel
Abstract
1.1 Introduction
1.2 Discovery of Pyrantel, Morantel, and Oxantel
1.3 Structure Activity Relationships
1.4 Synthesis of Tetrahydropyrimidine Drugs
1.5 Physicochemical Characteristics and Anthelmintic Activities
1.6 Conclusion
References Chapter 2. Pharmacology of Pyrantel
Abstract
2.1 Introduction
2.2 Pharmacology
2.3 Mechanism of Action
2.4 Resistance to Pyrantel and Morantel
References Chapter 3. The Safety of Pyrantel, Oxantel, and Morantel
Abstract
3.1 Introduction
3.2 Pyrantel
3.3 Oxantel
3.4 Morantel
3.5 Discussion
References Chapter 4. Formulations and Clinical Uses of Pyrimidine Compounds in Domestic Animals
Abstract
4.1 Introduction
4.2 Formulations
4.3 Clinical Uses of Pyrimidine Compounds in Domestic Animals
4.4 Conclusion
References Chapter 5. Pyrantel Parasiticide Therapy in Humans
Abstract
5.1 Introduction
5.2 Current Global Strategy to Control Human Soil-Transmitted Helminthiasis
5.3 Therapeutic Efficacy of PYR Against Human Soil-Transmitted Helminthiasis
5.4 Role of PYR as a Mass Administration Drug
5.5 Anthelmintic Resistance
5.6 Conclusions
References Chapter 6. Potential Applications of Tetrahydropyrimidines to Address Unmet Needs
Abstract
6.1 Expanded Label Claims in Equine Combinations—Tapeworm Activity
6.2 Combination Applications Against Resistant Parasites—Equine
References
Index
