Pyrantel Parasiticide Therapy in Humans and Domestic Animals

Pyrantel Parasiticide Therapy in Humans and Domestic Animals pdf

By Alan Marchiondo

Pyrantel Parasiticide Therapy in Humans and Domestic Animals PDF presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes.

Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970’s to control two important nematode groups, the hookworms and the roundworms.

Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.

  • Easy-to-use reference guide on the anthelmintic pyrantel for clinicians, parasitologists, and researchers in human and veterinary medicine
  • Addresses current issues of resistance, along with combination uses against anthelmintic resistant parasites
  • Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds
  • Includes a discussion on pyrantel’s potential role in combination therapies
  • Provides cutting-edge material, and will be an evolving area of scientific discussion of treatment options in the future

Read more: Handbook of Veterinary Pharmacology

Table of Contents

List of Contributors
Chapter 1. Discovery and Chemistry of Pyrantel, Morantel and Oxantel
1.1 Introduction
1.2 Discovery of Pyrantel, Morantel, and Oxantel
1.3 Structure Activity Relationships
1.4 Synthesis of Tetrahydropyrimidine Drugs
1.5 Physicochemical Characteristics and Anthelmintic Activities
1.6 Conclusion
Chapter 2. Pharmacology of Pyrantel
2.1 Introduction
2.2 Pharmacology
2.3 Mechanism of Action
2.4 Resistance to Pyrantel and Morantel
Chapter 3. The Safety of Pyrantel, Oxantel, and Morantel
3.1 Introduction
3.2 Pyrantel
3.3 Oxantel
3.4 Morantel
3.5 Discussion
Chapter 4. Formulations and Clinical Uses of Pyrimidine Compounds in Domestic Animals
4.1 Introduction
4.2 Formulations
4.3 Clinical Uses of Pyrimidine Compounds in Domestic Animals
4.4 Conclusion
Chapter 5. Pyrantel Parasiticide Therapy in Humans
5.1 Introduction
5.2 Current Global Strategy to Control Human Soil-Transmitted Helminthiasis
5.3 Therapeutic Efficacy of PYR Against Human Soil-Transmitted Helminthiasis
5.4 Role of PYR as a Mass Administration Drug
5.5 Anthelmintic Resistance
5.6 Conclusions
Chapter 6. Potential Applications of Tetrahydropyrimidines to Address Unmet Needs
6.1 Expanded Label Claims in Equine Combinations—Tapeworm Activity
6.2 Combination Applications Against Resistant Parasites—Equine

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