Animal Science
Ruminants’ Welfare Assessment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
G. Stilwell, A. Vieira, E. Can, C. Krug, S. Saraiva, M. Battini,
and S. Mattiello
Pain Management for Ruminants During Common Farm Husbandry
Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
G. Stilwell, P. Windsor, and D. M. Broom
Genetic Diversity and Structure of Iberoamerican Livestock Breeds . . . 52
L. T. Gama, A. M. Martinez, C. Ginja, J. Cañon, I. Martin-Burriel,
M. A. Revidatti, M. N. Ribeiro, J. Jordana, O. Cortes, N. Sevane,
V. Landi, J. V. Delgado, and the BIOBOVIS, BIOPIG, BIOHORSE,
BIODONKEY, BIOGOAT and BIOVIS consortia
Genetics of Carcass and Meat Quality Traits in Iberian Pigs. . . . . . . . . 69
M. C. Bressan, J. Almeida, A. Amaral, C. Bettencourt, J. Santos-Silva,
O. Moreira, R. Bessa, and L. T. Gama
The Fine Structure of the Cellulosome Defines the Intricacies
of Carbohydrate Deconstruction in the Mammalian Gut . . . . . . . . . . . . 87
P. Bule, S. Najmudin, J. Brás, V. Pires, V. Fernandes, A. Sequeira,
K. Cameron, A. Leitão, J. A. M. Prates, L. M. A. Ferreira, V. D. Alves,
and C. M. G. A. Fontes
Exogenous Enzymes Improve the Nutritive Value of Cereal-Based
Diets for Monogastric Animals Through Different
Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108
V. Cardoso, T. Ribeiro, V. Fernandes, C. Guerreiro, M. Centeno, V. Pires,
P. Ponte, A. Goyal, S. Najmudin, V. D. Alves, J. A. M. Prates,
L. M. A. Ferreira, and C. M. G. A. Fontes

Cistus ladanifer L. in Ruminant Diets – A Sustainable Approach
to Improve the Feed Nutritional Value and the Quality of Edible
Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128
E. Jerónimo, M. T. Dentinho, O. Guerreiro, A. Francisco, D. Soldado,
S. P. Alves, J. Santos-Silva, and R. J. B. Bessa
Ameliorating Pork Marbling and Quality with Novel Feeding
Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
M. S. Madeira, C. M. Alfaia, P. A. Lopes, J. Pestana, D. Coelho,
C. M. G. A. Fontes, and J. A. M. Prates
Growth and Development of the Lusitano Foal on Extensive
Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 178
M. J. Fradinho, R. J. B. Bessa, R. M. Caldeira, and G. Ferreira-Dias
Assisted Reproductive Technologies (ART) Directed to Germplasm
Preservation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
R. M. L. N. Pereira, C. C. Marques, J. Pimenta, J. P. Barbas,
M. C. Baptista, P. Diniz, A. Torres, and L. Lopes-da-Costa
Tropical Livestock Development: Mitigating Seasonal Weight Loss
and Health Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 216
L. A. Cardoso, A. Almeida, S. van Harten, and S. Zúquete
Animal Health, One Health
The Gut Microbiome and Antimicrobial Resistance in Companion
Animals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
A. Belas, C. Marques, and C. Pomba
Antimicrobial Resistance Trends in Dogs and Cats with Urinary
Tract Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 246
C. Marques, A. Belas, and C. Pomba
The Public Health Risk of Companion Animal to Human
Transmission of Antimicrobial Resistance During Different Types
of Animal Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265
C. Pomba, A. Belas, J. Menezes, and C. Marques
Antibacterial Alternatives in the Scope of One Health . . . . . . . . . . . . . . 279
M. Oliveira, I. Serrano, and L. Tavares
Domestic, Wildlife and Environmental Virology:
Molecular Epidemiology and Serological Surveillance . . . . . . . . . . . . . . 288
A. Duarte, M. C. Bento, S. Gil, and L. Tavares

Leishmaniosis: New Insights in a Changing World . . . . . . . . . . . . . . . . 301
G. Alexandre-Pires, M. Santos, M. A. Rodrigues, M. A. Pereira, J. Gomes,
S. A. Diaz, L. Gomes, A. Basso, A. Reisinho, J. Gomes, R. Leal,
J. Correia, A. Bolas, J. Meireles, G. Santos-Gomes,
and I. Pereira-da-Fonseca
Vectors and Vector Borne Diseases: Morphological and Molecular
Diagnosis, Risk Assessment, Population Genetics and Control
Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321
D. W. Ramilo, A. M. Alho, J. Gomes, M. Santos, A. S. Santos,
M. Santos-Silva, G. Alexandre-Pires, J. Meireles, A. Tomás, S. Zúquete,
A. Amaro, S. Belo, M. Schnyder, P. Deplazes, M. T. Rebelo,
L. Madeira-de-Carvalho, and I. Pereira-da-Fonseca
Distribution, Major Epidemiological Features and Control of Equid
Gastrointestinal Parasites in Mainland Portugal . . . . . . . . . . . . . . . . . . 344
A. S. Lopes, B. Melo-Franco, T. Nunes, S. Sousa, P. Fabrica, B. São-Braz,
and L. Madeira-de-Carvalho
Veterinary Medicine
From Villains to Heroes: Insights into the Antagonizing Functions
of Prion like Genes and Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 373
J. Pimenta, L. Lopes-da-Costa, C. C. Marques, J. P. Barbas,
M. C. Baptista, and R. M. L. N. Pereira
Unraveling Notch Signaling in Reproductive
Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
D. Murta, E. Silva, A. Trindade, D. Henrique, A. Duarte,
and L. Lopes-da-Costa
Endothelial Dll4/Notch Signaling as a Target for Cancer
and Wound Healing Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403
A. Trindade, D. Djokovic, L. Mendonça, M. Badenes, L. Lopes-da-Costa,
and A. Duarte
Feline Mammary Carcinoma: Past, Present and Future . . . . . . . . . . . . 419
A. Gameiro, F. Almeida, M. Soares, J. Correia, and F. Ferreira
Novel Diagnostic and Therapeutic Immunologic Strategies
to Overcome Infectious, Oncologic and Neurodegenerative
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 436
F. Aires-da-Silva, J. Dias, S. I. Aguiar, F. Marques, A. André, S. Gil,
and L. Tavares
Trends in Translational Medical Research: Companion Animal
Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 460
L. A. Mestrinho, E. Delgado, M. Lourenço, and M. Niza

Neuroprotection in Glaucoma – Is Erythropoietin the Solution? . . . . . . 475
A. P. Resende, B. R. Silva, B. São-Braz, and E. Delgado
No Room to Breathe: Airway Conditions Affecting the Equine
Athlete . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 485
P. Tilley, J. Simões, V. Pessoa, R. Fonseca, and J. P. Sales-Luis
The Role of Uteropathogenic Escherichia Coli in the Development
of Canine Pyometra . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 510
E. Silva, M. F. Silva, S. Henriques, P. Diniz, C. Carneiro,
L. Lopes-da-Costa, and L. Mateus
What Goes Wrong from a Mare Healthy Endometrium
to Endometrosis? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 528
G. Ferreira-Dias, M. R. Rebordão, A. M. Galvão, R. Roberto-da-Costa,
A. Amaral, C. Fernandes, P. Pinto-Bravo, S. Morazzo, G. Alexandre-Pires,
K. Lukasik, A. Szóstek-Mioduchowska, and D. J. Skarzynski
Pregnancy Toxaemia in Small Ruminants . . . . . . . . . . . . . . . . . . . . . . . 541
P. B. A. Simões, R. Bexiga, L. P. Lamas, and M. S. Lima
Historical Note
CIISA: A 25 Year Old Young Adult… or… A Dream on Veterinary
Science . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 559
Luis Tavares and All Researchers Working in CIISA 1992–2018
Author Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 573