Host-Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives
By Gottfried Unden, Eckhard Thines, Anja Schuffler and Paul M. Selzer
Host – Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives PDF. In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.
Table of Contents
Preface vii
Cover Legend ix
List of Contributors xi
Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction 1
1 Metabolic Adaptation of Human Pathogenic Yersiniae 3 Ann Kathrin Heroven and Petra Dersch*
2 Crosstalk between Metabolism and Virulence of Legionella pneumophila 19 Klaus Heuner and Wolfgang Eisenreich*
3 Metabolism of Intracellular Salmonella enterica 37 Peter Holtkötter and Michael Hensel*
4 The Human Microbiome in Health and Disease 57 Cian Hill, R. Paul Ross, Catherine Stanton, and Paul W. O’Toole*
5 Mechanisms of Dysbiosis in the Inflamed Gut 77 Sebastian E. Winter*
6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice 93 Andrew J. Foster, George R. Littlejohn, Darren M. Soanes, and Nicholas J. Talbot*
Part Two New Inhibitors and Targets of Infectious Diseases 109
7 Outer Membrane Proteins as Potential Anti-infective Drug Targets in Mannheimia haemolytica 111 Robert L. Davies*
8 Identification of Anti-infective Compounds Using Amoebae 139 Christopher F. Harrison and Hubert Hilbi*
9 Stress Biology in Fungi and “Omic” Approaches as Suitable Tools for Analyzing Plant–Microbe Interactions 153 Stefan Jacob* and Alexander Yemelin
10 Targeting Plasmids: NewWays to Plasmid Curing 179 Anja Schüffler* and Corinna Kübler
11 Regulation of Secondary Metabolism in the Gray Mold Fungus Botrytis cinerea 201 Muriel Viaud*, Julia Schumacher, Antoine Porquier, and Adeline Simon
