Host-Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives

Host-Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives

By Gottfried Unden, Eckhard Thines, Anja Schuffler and Paul M. Selzer

Host – Pathogen Interaction: Microbial Metabolism, Pathogenicity and Antiinfectives PDF. In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Table of Contents

Preface vii

Cover Legend ix

List of Contributors xi

Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction 1

1 Metabolic Adaptation of Human Pathogenic Yersiniae 3
Ann Kathrin Heroven and Petra Dersch*

2 Crosstalk between Metabolism and Virulence of Legionella pneumophila 19
Klaus Heuner and Wolfgang Eisenreich*

3 Metabolism of Intracellular Salmonella enterica 37
Peter Holtkötter and Michael Hensel*

4 The Human Microbiome in Health and Disease 57
Cian Hill, R. Paul Ross, Catherine Stanton, and Paul W. O’Toole*

5 Mechanisms of Dysbiosis in the Inflamed Gut 77
Sebastian E. Winter*

6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice 93
Andrew J. Foster, George R. Littlejohn, Darren M. Soanes, and Nicholas J. Talbot*

Part Two New Inhibitors and Targets of Infectious Diseases 109

7 Outer Membrane Proteins as Potential Anti-infective Drug Targets in Mannheimia haemolytica 111
Robert L. Davies*

8 Identification of Anti-infective Compounds Using Amoebae 139
Christopher F. Harrison and Hubert Hilbi*

9 Stress Biology in Fungi and “Omic” Approaches as Suitable Tools for Analyzing Plant–Microbe Interactions 153
Stefan Jacob* and Alexander Yemelin

10 Targeting Plasmids: NewWays to Plasmid Curing 179
Anja Schüffler* and Corinna Kübler

11 Regulation of Secondary Metabolism in the Gray Mold Fungus Botrytis cinerea 201
Muriel Viaud*, Julia Schumacher, Antoine Porquier, and Adeline Simon

Index 217

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