Tuberculosis, Leprosy and Mycobacterial Diseases of Man and Animals, The Many Hosts of Mycobacteria

Tuberculosis, Leprosy And Mycobacterial Diseases Of Man And Animals, The Many Hosts Of Mycobacteria

By Harshini Mukundan, Mark Chambers, Ray Waters and Michelle Larsen

Mycobacteria are bacterial pathogens which cause diseases in humans and non-human animals. This monograph will primarily cover the most important and widely researched groups of mycobacteria: members of the Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae, across a wide range of host species. M. tuberculosis and M. bovis are particularly relevant with the increasing drug resistance and co-infection with HIV associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis. This book will provide a reference for researchers working in different fields creating a work which draws together information on different pathogens, and by considering the diseases in a zoonotic context provides a One Health approach to these important groups of diseases.

Table of Contents

Introduction:

The Many Hosts of Mycobacteria:

An Interdisciplinary Approach to Understanding Mycobacterial Diseases

Part I: Tuberculosis in Humans

1: Introduction and Epidemiology of Mycobacterium tuberculosis Complex in Humans

2: Comparative Mycobacteriology of the Mycobacterium tuberculosis Complex

3: Immunopathogenesis of Tuberculosis in Humans

4: Current Methods for Diagnosis of Human Tuberculosis and Considerations for Global Surveillance

5: Development of Next-generation TB Vaccines: Comparative Approaches in Humans and Animals

6: The Continuing Co-evolution of Mycobacterium tuberculosis and Homo sapiens

Part II: Tuberculosis in Domesticated and Companion Animal Species

7: The Global Distribution of Mycobacterium bovis

8: Immunopathogenesis of Mycobacterium bovis Infection of Cattle

9: Diagnosis of Mycobacterium bovis Infection in Cattle

10: Vaccination of Cattle Against Tuberculosis

11: Mycobacterium bovis/M. caprae Infection in Goats and Sheep: Introduction, Epidemiology and Control Measures

12: Mycobacterial Infections in Camelids

13: Tuberculosis in Companion Animal Species

Part III: Mycobacterial Infections in Zoo Species

14: Mycobacterial Infections in Elephants

15: Mycobacterial Infections in Other Zoo Animals

Part IV: Tuberculosis in Wildlife

16: Tuberculosis in Badgers (Meles meles)

17: Tuberculosis in Pigs and Wild Boar

18: Australian Brushtail Possum: A Highly Susceptible Host for Mycobacterium bovis

19: Tuberculosis in Wild and Captive Deer

20: Tuberculosis in South African Wildlife: Lions, African Buffalo and Other Species

21: Novel Mycobacterium tuberculosis Complex spp. in Group-living African Mammals

Part V: In Vivo Laboratory Models of Tuberculosis

22: Rabbit Model of Mycobacterial Diseases

23: Laboratory Models of Tuberculosis: Guinea Pigs

24: Of Mice and Mycobacteria: Lessons from a Manipulatable Model

25: Non-human Primate Laboratory Models of Tuberculosis

Part VI: Other Mycobacterial Diseases

26: Mycobacterium leprae in Humans

27: Animal Models for Leprosy Research

28: Mycobacterium avium subsp. paratuberculosis Infection, Immunology and Pathology of Livestock

29: Nontuberculous Mycobacterial Infections

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