Histopathology of Preclinical Toxicity Studies, 4th Edition

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

  • This edition is in full color and features nearly 200 high-quality images
  • Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading
  • Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions
Table of Contents

Chapter 1. Introduction

References

Chapter 2. Integumentary System

Skin and subcutaneous tissue

References

Chapter 3. Mammary Gland

References

Chapter 4. Hemopoietic and Lymphatic Systems

Blood and bone marrow

Lymphoid system

Lymph nodes

Spleen

Thymus

Lymphoreticular neoplasms

References

Chapter 5. Musculoskeletal System

Bone

Joints

Skeletal muscle

References

Chapter 6. Respiratory Tract

Nose, nasal sinuses, nasopharynx and pharynx

Larynx and trachea

Bronchi and lungs

References

Chapter 7. Cardiovascular System

Heart and pericardium

Systemic blood vessels

Pulmonary blood vessels

References

Chapter 8. Digestive System

Mouth and oropharynx

Salivary glands

Esophagus

Forestomach

Stomach (glandular)

Small intestine

Large intestine

References

Chapter 9. Liver and Pancreas

Liver

Bile ducts, biliary system

Gallbladder

Exocrine pancreas

Endocrine Pancreas

References

Chapter 10. Urinary Tract

Kidney

Urinary bladder

Neoplasia

References

Chapter 11. Male Genital Tract

Prostate gland

Preputial (and clitoral) glands

Epididymis

Testis

References

Chapter 12. Female Genital Tract

Clitoral glands

Vagina

Cervix

Uterus

Ovary

References

Chapter 13. Endocrine Glands

Pituitary gland

Adrenal gland

Thyroid gland

Parathyroid gland

References

Chapter 14. Nervous System and Special Sense Organs

Brain

Spinal cord, spinal nerve roots and peripheral nerves

Eye

Ear

References

Index

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