By David Rollinson and Russell Stothard
Table of Contents
- Managing Zoonotic Diseases within and beyond African Wildlife Protected Areas
- Introduction
- The ‘Microscopic Five’
- Challenges of BTb Control at the Wildlife-Livestock Interface: The South African Case Study
- Drivers of Disease: The Kruger National Park Case Study
- Disease Knowledge Gaps and Lessons Learnt from African Protected Areas
- Communities and Conservation
- Conclusions
- Acknowledgements
- References
- Improving Translational Power in Antischistosomal Drug Discovery
- Filling the Drug Pipeline for Schistosomiasis
- Evaluating the Importance of S. mansoni Isolate Origin for Early Antischistosomal Drug Discovery
- The S. mansoni Mouse Model for Drug Efficacy Testing
- Infection Intensity of the Patent S. mansoni Mouse Model
- Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship of Selected Drugs
- Concluding Remarks
- Acknowledgements and Funding
- References
- Unique Thiol Metabolism in Trypanosomatids: Redox Homeostasis and Drug Resistance
- Introduction
- Trypanothione Metabolism
- Effector Proteins of the Antioxidant Defence: Old and New Actors
- Trypanothione Metabolism Linked to Cysteine, Polyamine, and Pentose Phosphate Pathway
- Role of Redox Active Compounds in Parasite Survival
- Role of Thiol Metabolism in Drug Resistance
- Anti-parasitic Potential of Molecules Targeted Against Redox Metabolism
- Unsolved Questions and Future Prospects
- Acknowledgements
- References
