Selegiline (l-Deprenyl)

Selegiline (l-Deprenyl) In Dogs & Cats: Uses, Dosage and Side Effects

Overview

Uses of Selegiline (l-Deprenyl)

• Authorized for treating behavioural disorders of purely emotional origin, including depression and anxiety.
• Used in association with behavior therapy for emotional signs in conditions like overactivity, separation problems, generalized phobia, and unsociable behavior.
• Characterized by modifications in feeding, drinking, autostimulatory behavior, sleep, exploratory behavior, aggression linked to fear and/or irritation, social behavior, and somatic disorders (e.g., tachycardia, emotional micturition).
• May enhance learning in specific contexts and is indicated for treating canine cognitive dysfunction, especially when anxiety and/or social withdrawal signs are present.
• Also used for treating signs of cognitive decline in older cats.
• Treatment can be stopped suddenly without gradual dose reduction.

Dose of Selegiline (l-Deprenyl) in Dogs and Cats

Dogs:

• 0.5–1 mg/kg p.o. q24h for a minimum of 2 months.

Cats:

• 1 mg/kg p.o. q24h.

Side Effects of Selegiline (l-Deprenyl) in Dogs and Cats

• No information is available.

Contraindications of Selegiline (l-Deprenyl) in Dogs and Cats

• Selegiline should not be used in animals with a known sensitivity to the drug or administered to lactating or pregnant bitches as it may act on prolactin secretion.

Some Notes:

• Do not administer Selegiline with alpha-2 antagonists (or within 24 hours before or after their use), pethidine, ephedrine, potential monoamine oxidase inhibitors (e.g., amitraz), or phenothiazines.
• The effect of morphine is potentiated when used simultaneously with Selegiline.
• Potential interactions may exist with metronidazole, prednisolone, and trimethoprim.
• Avoid using Selegiline for at least 2–3 weeks after the use of tricyclic antidepressants (e.g., amitriptyline, doxepin, clomipramine), or 6 weeks after the long-term use of fluoxetine.