Rabacfosadine

Rabacfosadine In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Prodrug of the nucleotide analogue PMEG; causes cytotoxicity in dividing cells due to inhibition of DNA polymerases.

Uses of Rabacfosadine

• Rabacfosadine has been trialled in canine lymphoma (B and T cell) and multiple myeloma.

Dose of Rabacfosadine in Dogs and Cats

Dogs:

• 0.82–1 mg/kg i.v. over 30 min once every 21 days.
• Has been used in combination with doxorubicin at weeks 0, 6, 12 as part of an alternating protocol.

Cats:

• Unknown.

Side Effects of Rabacfosadine in Dogs and Cats

• May cause myelosuppression and gastrointestinal adverse events (including haemorrhagic gastroenteritis).
• Liver enzyme activity elevation, azotaemia, fever, weight loss, lethargy, dermatological signs, pulmonary fibrosis, injected sclera and urinary signs/proteinuria/glycosuria are also reported.

Contraindications of Rabacfosadine in Dogs and Cats

• Contraindicated in patients with known hypersensitivity.
• Do not use in patients with pre-existing bone marrow suppression or liver dysfunction.
• Do not use in patients with known pulmonary disease or those susceptible to pulmonary fibrosis.

Some Notes: