Osaterone

Osaterone In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Competitively prevents the binding of androgens to their prostatic receptors and blocks the transport of testosterone into the prostate.

Uses of Osaterone

• Treatment of benign prostatic hypertrophy (BPH) in male dogs.
• In dogs with BPH associated with prostatitis, osaterone can be administered concurrently with antimicrobials.
• Quick onset of the decrease in size (40% reduction within 2 weeks) without loss of
  fertility.
• Non-invasive treatment that can be used in dogs that are not fit for surgical castration or that are still used as stud dogs.
• The effects of treatment last for about 6 months.
• Use with caution in dogs with a history of liver disease.

Dose of Osaterone in Dogs and Cats

Dogs:

• Benign prostatic hypertrophy: 0.25–0.5 mg/kg q24h for 7 days.

Cats:

• No indication.

Side Effects of Osaterone in Dogs and Cats

• Osaterone may temporarily drop plasma cortisol levels, which could persist for several weeks after the drug is given.
• It’s essential to closely monitor dogs experiencing stress (e.g., post-surgery) or those with hypoadrenocorticism when using this medication.
• The response to an ACTH stimulation test may remain suppressed for several weeks following osaterone administration.
• Common side effects encompass increased appetite, alterations in behaviour, momentary bouts of vomiting and/or diarrhoea, excessive urination and drinking, lethargy, and the development of feminization-related symptoms like mammary gland hyperplasia.
• Some dogs with liver issues treated with osaterone have experienced reversible elevations in ALT and ALP levels.

Contraindications of Osaterone in Dogs and Cats

• No information available