Phosphate (Toldimphos)

Phosphate (Toldimphos) In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Phosphate is essential for intermediary metabolism, ATP production, DNA and RNA synthesis, nerve, muscle and RBC function.
• Phosphate is filtered by the kidneys but 80% is resorbed.

Uses of Phosphate (Toldimphos)

• To correct hypophosphataemic states.
• To supplement patients on large volumes i.v. fluid therapy that have inadequate intake or patients that become hypophosphataemic following administration of insulin therapy or parenteral nutrition.
• In diabetic ketoacidotic patients, a combination of potassium chloride and potassium phosphate in equal parts may be indicated to meet the patient’s potassium needs and to treat or prevent significant hypophosphataemia.

Dose of Phosphate (Toldimphos) in Dogs and Cats

Dogs:

• Acute severe hypophosphataemia: 0.06–0.18 mmol/kg of potassium phosphate i.v. over 6 hours, adjust according to response.
• Chronic hypophosphataemia: 140–280 mg (1–2 ml) i.m., s.c. q48h for 5–10 doses, 0.5–2 mmol phosphate/kg/day p.o.

Cats:

• Acute severe hypophosphataemia: dose as for dogs.
• Chronic hypophosphataemia: 0.5–2 mmol phosphate/kg/day p.o.

Side Effects of Phosphate (Toldimphos) in Dogs and Cats

• May result in hypotension, renal failure or metastatic calcification of soft tissue.
• Hyperkalaemia or hypernatraemia may result in patients predisposed to these
  abnormalities and monitoring of electrolyte profiles is needed.
• Overdose or administration to patients with renal compromise may lead to hyperphosphataemia.

Contraindications of Phosphate (Toldimphos) in Dogs and Cats

• Hyperphosphataemia, hypocalcemia, oliguric renal failure or if significant tissue necrosis is present.

Some Notes:

• Phosphates are incompatible with metals, including calcium and magnesium.