Phenylpropanolamine

Phenylpropanolamine In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Sympathomimetic – increases urethral outflow resistance and has some peripheral vasoconstrictive effects.

Uses of Phenylpropanolamine

• Treatment of urinary incontinence secondary to urethral sphincter incompetence.

Dose of Phenylpropanolamine in Dogs and Cats

Dogs:

• Urethral sphincter incompetence: 0.8 mg phenylpropanolamine/kg (equivalent to 1 mg/kg phenylpropanolamine hydrochloride/kg) p.o. q8h or 1.2 mg/kg phenylpropanolamine/kg (equivalent to 1.5 mg/kg phenylpropanolamine hydrochloride/kg) p.o. q12h.

Cats:

• Urethral sphincter incompetence: (extra-label) doses as for dogs.

Side Effects of Phenylpropanolamine in Dogs and Cats

• It may include restlessness, aggressiveness, irritability, gastrointestinal signs and hypertension.
• Cardiotoxicity has been reported.

Contraindications of Phenylpropanolamine in Dogs and Cats

• No information is available.

Some Notes:

• Concurrent administration with estriol may potentiate efficacy.
• Incontinence may recur if doses are delayed or missed.
• The onset of action may take several days.
• Use with caution in the presence of cardiovascular disease, renal or hepatic insufficiency, glaucoma, diabetes mellitus, or hyperthyroidism.