Framycetin

Framycetin: Uses, Dosage and Side Effects

Overview

• Aminoglycosides inhibit bacterial protein synthesis and require an oxygen-rich environment to be effective.
• They are ineffective in low-oxygen sites (abscesses, exudates), making all obligate anaerobic bacteria resistant.
• Their mechanism of killing is concentration-dependent, leading to a marked post-antibiotic effect, allowing pulse-dosing regimens which may limit toxicity

Uses of Framycetin

• Treatment of aural infections.
• Framycetin is particularly effective against Gram-negative bacteria, although the combination preparation Canaural has a broad spectrum of activity.

Dose of Framycetin in Dogs and Cats

Dogs, Cats:

• 5–10 drops per ear q12h.
• In small animals, 2–5 drops may be a more feasible volume to instill.

Side Effects of Framycetin in Dogs and Cats

• Aminoglycosides are potentially ototoxic, and ataxia, deafness and nystagmus may be observed in animals where drops have been administered with a perforated tympanum.
• Local irritation.

Contraindications of Framycetin in Dogs and Cats

• Do not use in animals with a perforated tympanum.
• Do not use it in conjunction with other products known to be ototoxic.