Edetate Calcium Disodium (CaEDTA)

Edetate calcium disodium
(CaEDTA): Uses, Dosage and Side Effects

Overview

• Heavy metal chelating agent.

Uses of Edetate calcium disodium (CaEDTA)

• Treatment of lead and zinc poisoning.
• Dilute strong solution to a concentration of 10 mg/ml in 5% dextrose before use.
• Blood lead levels may be confusing, therefore, monitor clinical signs during therapy.
• Measure blood lead levels 2–3 weeks after completion of treatment in order to determine whether a second course is required or if the animal is still being exposed to
  lead.
• Ensure there is no lead in the GI tract before administering (e.g. use laxatives).

Dose of Edetate calcium disodium (CaEDTA) in Dogs and Cats

Dogs, Cats:

• Lead or zinc toxicity: 25 mg/kg s.c. q6h for 2–5 days.
  The total daily dose should not exceed 2 g.
• Dogs that respond slowly or have an initial (pretreatment) blood lead level of >4.5 μmol/l may need another 5-day course of treatment after a rest period of 5 days.

Side Effects of Edetate calcium disodium (CaEDTA) in Dogs and Cats

• Reversible nephrotoxicity is usually preceded by other clinical signs of toxicity (e.g. depression, vomiting, diarrhoea).
• Dogs showing GI effects may benefit from zinc supplementation.
• Injections are painful.

Contraindications of Edetate calcium disodium (CaEDTA) in Dogs and Cats

• Use with caution in patients with impaired renal function.