Asparaginase (l-Asparginase, Crisantaspase)

Asparaginase (l-Asparginase, Crisantaspase): Uses, Dosage and Side Effects

Overview

Lymphoid tumor cells are not able to synthesize asparagine and are dependent upon supply from the extracellular fluid. Asparaginase deprives malignant cells of this amino acid, which results in the cessation of protein synthesis and cell death.

Uses of Asparaginase (l-Asparginase, Crisantaspase)

Treatment of lymphoid malignancies.

Dose of Asparaginase (l-Asparginase, Crisantaspase) in Dogs and Cats

Dogs, Cats:

• 10,000 IU/m2 or 400 IU/kg i.m. or s.c. q7d or less frequently.

Side Effects of Asparaginase (l-Asparginase, Crisantaspase) in Dogs and Cats

• Anaphylaxis may follow administration, especially if repeated.
• Premedication with an antihistamine is recommended 30 minutes before administration.
• Hemorrhagic pancreatitis has been reported in dogs.
• Gastrointestinal disturbances, hepatotoxicity including acute hyperammonaemia (presenting with encephalopathy) and coagulation deficits may also be observed.
• Bone marrow depression is very rare.

Contraindications of Asparaginase (l-Asparginase, Crisantaspase) in Dogs and Cats

• Patients with active pancreatitis or a history of pancreatitis.
• History of anaphylaxis associated with previous administration.
• Use with caution in patients with pre-existing liver dysfunction.

Some Notes:

• Administration with or before vincristine may reduce clearance of vincristine and increase toxicity; thus, if used in combination, the vincristine should be given 12–24 hours before the enzyme.