Sevelamer Hydrochloride

Sevelamer hydrochloride In Dogs & Cats: Uses, Dosage and Side Effects

Overview

• Sevelamer is an organic ion-exchange resin that binds intestinal phosphate.

Uses of Sevelamer hydrochloride

• Reduction of serum phosphate in azotaemia.
• Hyperphosphatemia contributes to chronic renal failure progression.
• Phosphate-binding agents are reserved for cases where low phosphate diets fail.
• Regularly monitor serum phosphate levels every 4–6 weeks.
• Adjust medication dosage to achieve target serum concentrations.
• Be aware that these agents may hinder vitamin absorption, notably vitamin K.
• Consider monitoring prothrombin time due to potential vitamin K interference.

Dose of Sevelamer hydrochloride in Dogs and Cats

Dogs, Cats:

• Chronic kidney disease: 30–40 mg/kg p.o. q8h, titrated to the desired serum phosphate concentration.
• Should be given with meals and at least 1 hour before or 3 hours after other medications.

Side Effects of Sevelamer hydrochloride in Dogs and Cats

• Pills are hygroscopic and will expand.
• Constipation is possible.

Contraindications of Sevelamer hydrochloride in Dogs and Cats

• GI obstruction.