Trends and Advances in Veterinary Genetics – Cheryl Natividad

List of Figures……………………………………………………………………………………………ix
List of Tables………………………………………………………………………………………….. xxi
Preface……………………………………………………………………………………………. ….xxiii
Chapter 1 Introduction…………………………………………………………………………………..1
Chapter 2 Review of Genetics and Its
Significance to Veterinary Medicine………………………………………………….5
2.1 Deoxyribonucleic Acid (DNA): The Genetic Material……………………….6
2.2 Central Dogma of Molecular Biology…………………………………………..10
2.3 Mutations in the Genetic Message………………………………………………14
2.4 Chromosomes as Genetic Elements…………………………………………….15
2.5 Cell Division and its Genetic Implications……………………………………17
2.6 Significance of Genetics in Veterinary Medicine……………………………21
Reference…………………………………………………………………………………….23
Chapter 3 Genetics and Disease…………………………………………………………………….25
3.1 The Genetic Basis of Disease In Animals………………………………………26
3.2 Genetic Tools to Diagnose Genetic Disorders……………………………….40
3.3 Genetic Tools to Treat Genetic Disorders………………………………………52
References……………………………………………………………………………………64
Chapter 4 Genetics and Immunity………………………………………………………………….69
4.1 Major Defense Barriers……………………………………………………………..71
4.2 Understanding the Immunogenetics of Leprosy Using
Animal Models……………………………………………………………………..95
4.3 Animal Models for HIV Infection or AIDS…………………………………..102
References………………………………………………………………………………….110

Chapter 5 Sequencing The Genome of Domestic Animals………………………………..115
5.1 Sequencing Technologies…………………………………………………………116
5.2 Analyzing Genomic Data………………………………………………………..124
5.3 Significance of Sequencing Domestic Animal Genomes……………….127
5.4 Sequencing the Genome of Domestic Animals……………………………129
References………………………………………………………………………………….146
Chapter 6 Veterinary Pharmacogenetics and Pharmacogenomics……………………..147
6.1 Significance of Pharmacogenomics……………………………………………148
6.2 Data Generation and Analysis in Pharmacogenomics…………………..150
6.3 Animal Models of Pharmacogenomics……………………………………….157
6.4 Limitations of Animal Models…………………………………………………..165
References………………………………………………………………………………….167
Chapter 7 Veterinary Nutrigenomics…………………………………………………………….169
7.1 Diet and Gene Expression………………………………………………………..170
References………………………………………………………………………………….178
Chapter 8 Veterinary Epigenetics………………………………………………………………….179
8.1 Epigenetic Mechanisms…………………………………………………………..180
8.2 Animal Models in Epigenetics…………………………………………………..189
8.3 Epigenetics in Cloned Animals………………………………………………….191
8.4 Epigenome and The Environment………………………………………………194
8.5 Epigenetics and Animal Behavior………………………………………………197
8.6 Epigenetics and Immunity………………………………………………………..200
8.7 Epigenetics and Cancer……………………………………………………………200
References………………………………………………………………………………….203
Index…………………………………………………………………………………………205